Descrição das lesões microscópicas das pregas vestibulares de adultos autopsiados e sua relação com as causas de óbito e doença de base

Abstract

The increasing in the invasive methods currently applied to diagnosis airway uppert tract infection leads to a possible increase in the vestibular folds (VF) lesions. Besides, the VF importance in the prevention of the organism against infection pathogens had been stressed and few studies had addressed the microscopic lesions of the VF in autopsied patients because there is no routine VF examination in the post mortem exam. Aim: The aim of this study is the morphological microscopic analyses of the VF from autopsied patients and its correlation with the basic disease and the cause of death. Study design: transversal cohort. Material and Method: We studied 82 larynges collected during the autopsy exam and performed the Hematoxylin - eosin method for morphological analyses. Results: From the 82 vestibular folds analyzed we observe that 42 (51%) showed a inflammatory reaction. In fifteen (18.3%) vestibular folds we found lymphoid follicular hyperplasia, in eleven (13.4%) diffuse inflammatory infiltrate and in sixteen (19.5%) acute inflammatory reaction. The circulatory diseases were the most frequently basics diseases found, 31 (37.8%) and from these 20 (67.8%) presented associated vestibular folds inflammatory reaction. The infection diseases were the most frequently cause of death among the patients with inflammatory reaction of the VF. Conclusion: Besides the anatomic function the VF seems to have a immunological function preventing lower airway infections. Our study demonstrated a inflammatory PV reaction in patients with infections diseases as a cause of death, this finding could be a consequence of the sepses that leads the patient to death or a different way which the organism used to prevent infection.