Multicomponent synthesis of spiro 1,3,4-thiadiazolines with anticancer activity by using deep eutectic solvent under microwave irradiation

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dc.creatorCastro, Aleff Cruz de
dc.creatorAndrade, Isadora Maria Gouveia
dc.creatorCoelho, Maísa Cavalcanti
dc.creatorCosta, Daniel Pereira da
dc.creatorMoreira, Dayse das Neves
dc.creatorMaia, Rachel Azevedo
dc.creatorLima, Gesiane da Silva
dc.creatorSantos, Gabriel Franco dos
dc.creatorVaz, Boniek Gontijo
dc.date.accessioned2023-07-20T10:29:50Z
dc.date.available2023-07-20T10:29:50Z
dc.date.issued2022
dc.description.abstractThis work describes a simple and efficient alternative method for obtaining 1,3,4-thiadialzolinic spirocompounds, combining the use of deep eutectic solvents (DES) with microwave irradiation in a one-pot process. A series of DES based on different acids was explored as a solvent in a three-component reaction including isatin derivatives (monomeric and dimeric), thiosemicarbazide, and acetic anhydride. Choline chloride and oxalic acid (1:1) showed better results concerning the other solvents evaluated, reaching yields of up to 79% when applied to the other compounds of the proposed series. For most of the monomeric compounds, the yields were very close to or higher than those reported in the literature for two-step synthesis. These results demonstrate the possibility of using one-pot synthesis as a faster, cleaner, and more efficient alternative method for obtaining thiadiazolines with expressive cytotoxic activity.pt_BR
dc.identifier.citationCASTRO, Aleff et al. Multicomponent synthesis of spiro 1,3,4-thiadiazolines with anticancer activity by using deep eutectic solvent under microwave irradiation. Journal of Heterocyclic Chemistry, Bangalore, v. 60, n. 3, p. 392-405, 2022. DOI: 10.1002/jhet.4591. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/jhet.4591. Acesso em: 28 jun. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.1002/jhet.4591
dc.identifier.issne- 1943-5193
dc.identifier.issn0022-152X
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/jhet.4591
dc.language.isoengpt_BR
dc.publisher.countryOutrospt_BR
dc.publisher.departmentInstituto de Química - IQ (RMG)pt_BR
dc.rightsAcesso Restritopt_BR
dc.titleMulticomponent synthesis of spiro 1,3,4-thiadiazolines with anticancer activity by using deep eutectic solvent under microwave irradiationpt_BR
dc.typeArtigopt_BR

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