Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia

dc.creatorSiqueira, Elis Regina Lima
dc.creatorPinheiro, Willie Oliveira
dc.creatorAquino, Victor Raul Romero
dc.creatorCoelho, Breno Cunha Pinto
dc.creatorBakuzis, Andris Figueiroa
dc.creatorAzevedo, Ricardo Bentes
dc.creatorSousa, Marcelo Henrique
dc.creatorMorais, Paulo Cesar de
dc.date.accessioned2023-04-13T12:42:28Z
dc.date.available2023-04-13T12:42:28Z
dc.date.issued2022
dc.description.abstractThis study investigated the fabrication of spherical gold shelled maghemite nanoparticles for use in magnetic hyperthermia (MHT) assays. A maghemite core (14 3 nm) was used to fabricate two samples with different gold thicknesses, which presented gold (g)/maghemite (m) content ratios of 0.0376 and 0.0752. The samples were tested in MHT assays (temperature versus time) with varying frequencies (100–650 kHz) and field amplitudes (9–25 mT). The asymptotic temperatures (T¥) of the aqueous suspensions (40 mg Fe/mL) were found to be in the range of 59–77 C (naked maghemite), 44–58 C (g/m = 0.0376) and 33–51 C (g/m = 0.0752). The MHT data revealed that T¥ could be successful controlled using the gold thickness and cover the range for cell apoptosis, thereby providing a new strategy for the safe use of MHT in practice. The highest SAR (specific absorption rate) value was achieved (75 kW/kg) using the thinner gold shell layer (334 kHz, 17 mT) and was roughly twenty times bigger than the best SAR value that has been reported for similar structures. Moreover, the time that was required to achieve T¥ could be modeled by changing the thermal conductivity of the shell layer and/or the shape/size of the structure. The MHT assays were pioneeringly modeled using a derived equation that was analytically identical to the Box–Lucas method (which was reported as phenomenological).pt_BR
dc.identifier.citationSIQUEIRA, Elis Regina Lima et al. Engineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermia. Nanomaterials, Basel, v. 12, n. 16, e2760, 2022. DOI: doi: 10.3390/nano12162760. Disponível em: https://www-ncbi-nlm-nih.ez49.periodicos.capes.gov.br/pmc/articles/PMC9413094/pdf/nanomaterials-12-02760.pdf. Acesso em: 11 abr. 2023.pt_BR
dc.identifier.doi10.3390/nano12162760
dc.identifier.issne- 2079-4991
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/22312
dc.language.isoengpt_BR
dc.publisher.countrySuicapt_BR
dc.publisher.departmentInstituto de Física - IF (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMagnetic hyperthermiapt_BR
dc.subjectBox–Lucas modelpt_BR
dc.subjectMagnetic fluidpt_BR
dc.subjectAsymptotic temperaturept_BR
dc.subjectMaghemitept_BR
dc.subjectCore–shellpt_BR
dc.titleEngineering gold shelled nanomagnets for pre-setting the operating temperature for magnetic hyperthermiapt_BR
dc.typeArtigopt_BR

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