Avaliação do efeito da clorpromazina sobre a função renal de cães submetidos à isquemia e reperfusão
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Data
2010-02
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Editor
Colégio Brasileiro de Patologia Animal - Empresa Brasileira de Pesquisa Agropecuária
Resumo
Renal ischemia may occur in different situations such as vascular or renal surgery and also in renal transplantation. This study evaluates renal function in dogs submitted to ischemia and reperfusion after chlorpromazine application. Twelve adult mongrel dogs were distributed into two groups with six animals each. Group A was composed of dogs submitted to renal ischemia and reperfusion without previous administration of chlorpromazine. Group B was composed of dogs with renal ischemia and reperfusion
previously treated with chlorpromazine. In order to evaluate the possible ischemia/ reperfusion late effects, blood and urine samples were sampled in four different times: Before ischemia, early stages of reperfusion, 120 minutes after reperfusion, and every week until 28th day postsurgery. Renal function was evaluated by clinical examination, serum urea and creatinine levels and urinary GGT activity. PU/CU and GGT urinary activity were more sensitive in detecting acute tubular injury than routine urine examination because these variables showed earlier changes. Based on urinalysis, urea and creatinine serum levels plus urinary excretion of GGT and PU/CU, no evidences of protective action of chlorpromazine were observed.
Descrição
Palavras-chave
Fenotiazínico, Gama-glutamiltransferase, Insuficiência renal, Fenotiazinic, Gamma-glutamiltransferase, Acute renal failure
Citação
MENEZES, Liliana B. de; FIORAVANTI, Maria Clorinda S.; SILVA, Marcelo S. de Brito; FRANCO; Leandro G.; SALES, Tatyane Penha; ANDRASCKO, Mariana M.; VEADO, Júlio César C.; ARAÚJO, Eugênio G. Avaliação do efeito da clorpromazina sobre a função renal de cães submetidos à isquemia e reperfusão. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 30, n. 2, p. 108-114, fev. 2010.