Monocyte and macrophage-mediated pathology and protective immunity during schistosomiasis
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2020
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Resumo
Infection by Schistosoma parasites culminates in a chronic granulomatous disease
characterized by intense tissue fibrosis. Along the course of schistosomiasis, diverse
leukocytes are recruited for inflammatory foci. Innate immune cell accumulation
in Th2-driven granulomas around Schistosoma eggs is associated with increased
collagen deposition, while monocytes and macrophages exert critical roles during this
process. Monocytes are recruited to damaged tissues from blood, produce TGF-β and
differentiate into monocyte-derived macrophages (MDMs), which become alternatively
activated by IL-4/IL-13 signaling via IL-4Rα (AAMs). AAMs are key players of tissue
repair and wound healing in response to Schistosoma infection. Alternative activation
of macrophages is characterized by the activation of STAT6 that coordinates the
transcription of Arg1, Chi3l3, Relma, and Mrc1. In addition to these markers, monocyte derived AAMs also express Raldh2 and Pdl2. AAMs produce high levels of IL-10 and
TGF-β that minimizes tissue damage caused by Schistosoma egg accumulation in
tissues. In this review, we provide support to previous findings about the host response
to Schistosoma infection reusing public transcriptome data. Importantly, we discuss the
role of monocytes and macrophages with emphasis on the mechanisms of alternative
macrophage activation during schistosomiasis.
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Monocyte, Alternatively activated macrophage, IL-4Rα, Fibrosis, Transcriptomics, Schistosomiasis
Citação
SOUZA, Camila Oliveira Silva et al. Monocyte and macrophage-mediated pathology and protective immunity during schistosomiasis. Frontiers in Microbiology, Lausanne, v. 11, e1973, 2020. DOI: 10.3389/fmicb.2020.01973. Disponível em: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.01973/full. Acesso em: 29 jan. 2025.