Monocyte and macrophage-mediated pathology and protective immunity during schistosomiasis

dc.creatorSouza, Camila Oliveira Silva
dc.creatorGardinassi, Luiz Gustavo Araujo
dc.creatorRodrigues, Vanderlei
dc.creatorFaccioli , Lúcia Helena
dc.date.accessioned2025-02-04T15:45:21Z
dc.date.available2025-02-04T15:45:21Z
dc.date.issued2020
dc.description.abstractInfection by Schistosoma parasites culminates in a chronic granulomatous disease characterized by intense tissue fibrosis. Along the course of schistosomiasis, diverse leukocytes are recruited for inflammatory foci. Innate immune cell accumulation in Th2-driven granulomas around Schistosoma eggs is associated with increased collagen deposition, while monocytes and macrophages exert critical roles during this process. Monocytes are recruited to damaged tissues from blood, produce TGF-β and differentiate into monocyte-derived macrophages (MDMs), which become alternatively activated by IL-4/IL-13 signaling via IL-4Rα (AAMs). AAMs are key players of tissue repair and wound healing in response to Schistosoma infection. Alternative activation of macrophages is characterized by the activation of STAT6 that coordinates the transcription of Arg1, Chi3l3, Relma, and Mrc1. In addition to these markers, monocyte derived AAMs also express Raldh2 and Pdl2. AAMs produce high levels of IL-10 and TGF-β that minimizes tissue damage caused by Schistosoma egg accumulation in tissues. In this review, we provide support to previous findings about the host response to Schistosoma infection reusing public transcriptome data. Importantly, we discuss the role of monocytes and macrophages with emphasis on the mechanisms of alternative macrophage activation during schistosomiasis.
dc.identifier.citationSOUZA, Camila Oliveira Silva et al. Monocyte and macrophage-mediated pathology and protective immunity during schistosomiasis. Frontiers in Microbiology, Lausanne, v. 11, e1973, 2020. DOI: 10.3389/fmicb.2020.01973. Disponível em: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.01973/full. Acesso em: 29 jan. 2025.
dc.identifier.doi10.3389/fmicb.2020.01973
dc.identifier.issne- 1664-302X
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/26523
dc.language.isoeng
dc.publisher.countrySuica
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMonocyte
dc.subjectAlternatively activated macrophage
dc.subjectIL-4Rα
dc.subjectFibrosis
dc.subjectTranscriptomics
dc.subjectSchistosomiasis
dc.titleMonocyte and macrophage-mediated pathology and protective immunity during schistosomiasis
dc.typeArtigo

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