Increased neutrophil influx but no impairment of protective immunity to tuberculosis in mice lacking the CD44 molecule
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Data
2003
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Resumo
Up-regulation of expression of the cellsurface
marker CD44 is a major characteristic of T
lymphocytes responding in the lungs of mice infected
with Mycobacterium tuberculosis. These
lymphocytes express an activated/memory phenotype
as seen by their high expression of the CD44
molecule and low expression of CD62L and
CD45RB cell-surface molecules. Based on increasing
evidence that the CD44 molecule participates
in several aspects of the inflammatory response, we
evaluated its role in the response to infection with
M. tuberculosis using gene-disrupted mice. In this
report, we show that CD44 expression is not necessary
for the proper trafficking of protective cells
to the lungs of mice infected with M. tuberculosis or
the direct expression of protective immunity leading
to control and containment of the bacterial
load in this organ. However, although there were
no differences in the bacterial load or migration of
activated T lymphocytes to the inflamed lung, the
absence of the CD44 molecule resulted in a substantially
increased accumulation of neutrophils in
the lung. These data indicate that loss of CD44
expression does not alter expression of T helper
cell type 1 immunity to tuberculosis in the lungs
but has major effects on the overall cellular composition
of the immunopathological response.
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Palavras-chave
Mouse, Lung inflammation, Tuberculosis infection, Cell recruitment, Lung
Citação
KIPNIS, Andre et al. Increased neutrophil influx but no impairment of protective immunity to tuberculosis in mice lacking the CD44 molecule. Journal of Leukocyte Biology, New York, v. 74, n.6, p. 992-997, Dec. 2003.