Evaluating the OGG1 rs1052133 and rs293795 polymorphisms in a sample of rural workers from Central Brazil population: a comparative approach with the 1000 Genomes Project

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dc.creatorSilva, Daniela de Melo e
dc.creatorAlves, Alessandro Arruda
dc.creatorNunes, Hugo Freire
dc.creatorRamos, Jheneffer Sonara Aguiar
dc.creatorFranco, Fernanda Craveiro
dc.creatorSoares, Thannya Nascimento
dc.date.accessioned2023-08-31T14:43:36Z
dc.date.available2023-08-31T14:43:36Z
dc.date.issued2018
dc.description.abstractBrazilian population is one of the largest consumers of pesticides in the world, especially the Central Brazil population. Thus, the aim of this study was to evaluate the frequency of genotypes, alleles, haplotypes, and the linkage disequilibrium (DL) of the OGG1 gene in rural workers from Central Brazil, comparing with the populations of the 1000 genome. Three hundred thirty healthy individuals not related and randomly selected were included in this study. We obtained genomic DNA from peripheral blood lymphocytes. The 748-bp OGG1 gene was amplified by PCR and sequenced. Of the 330 individuals, 215 (65%) were males and 115 (35%) were females. There were no differences in the distribution of the rs1052133 and rs293795 with age and sexes. Haplotypes containing only conserved T/C alleles were the most common in our population. The frequency of the mutant alleles of rs1052133 and rs293795, in our population, was 20% and 30%, respectively, and it is noteworthy, worldwide, that mutant alleles are commonly associated to an increased risk for the development of cancer, specially due to direct or indirect contact to pesticides, as occurs in rural workers of Central Brazil population.pt_BR
dc.identifier.citationSILVA, Daniela de Melo e et al. Evaluating the OGG1 rs1052133 and rs293795 polymorphisms in a sample of rural workers from Central Brazil population: a comparative approach with the 1000 Genomes Project. Environmental Science and Pollution Research, Berlim, v. 24, p. 25612–25617, 2018. DOI: 10.1007/s11356-018-2766-8. Disponível em: https://link.springer.com/article/10.1007/s11356-018-2766-8. Acesso em 30 ago. 2023.pt_BR
dc.identifier.doi10.1007/s11356-018-2766-8
dc.identifier.issn0944-1344
dc.identifier.issn1614-7499
dc.identifier.urihttps://link.springer.com/article/10.1007/s11356-018-2766-8
dc.language.isoengpt_BR
dc.publisher.countryAlemanhapt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RMG)pt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectRepairpt_BR
dc.subjectPesticidespt_BR
dc.subjectGenotypept_BR
dc.subjectCentral Brazilpt_BR
dc.subjectDistributionpt_BR
dc.subjectRisk populationpt_BR
dc.titleEvaluating the OGG1 rs1052133 and rs293795 polymorphisms in a sample of rural workers from Central Brazil population: a comparative approach with the 1000 Genomes Projectpt_BR
dc.typeArtigopt_BR

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