A polyalanine peptide derived from polar fish with anti-infectious activities

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dc.creatorCardoso, Marlon Henrique e Silva
dc.creatorRibeiro, Suzana Meira
dc.creatorSilva, Diego Oliveira Nolasco da
dc.creatorFuente Nunez, César de la
dc.creatorFelício, Mário Romão
dc.creatorGonçalves, Sónia
dc.creatorMatos, Carolina Oliveira
dc.creatorLiao, Luciano Morais
dc.creatorSantos, Nuno C.
dc.creatorFranco, Octavio Luiz
dc.creatorMigliolo, Ludovico
dc.creatorHancock, Robert E. W.
dc.date.accessioned2024-03-07T13:19:42Z
dc.date.available2024-03-07T13:19:42Z
dc.date.issued2016-02-26
dc.description.abstractDue to the growing concern about antibiotic-resistant microbial infections, increasing support has been given to new drug discovery programs. A promising alternative to counter bacterial infections includes the antimicrobial peptides (AMPs), which have emerged as model molecules for rational design strategies. Here we focused on the study of Pa-MAP 1.9, a rationally designed AMP derived from the polar fish Pleuronectes americanus. Pa-MAP 1.9 was active against Gram-negative planktonic bacteria and biofilms, without being cytotoxic to mammalian cells. By using AFM, leakage assays, CD spectroscopy and in silico tools, we found that Pa-MAP 1.9 may be acting both on intracellular targets and on the bacterial surface, also being more efficient at interacting with anionic LUVs mimicking Gram-negative bacterial surface, where this peptide adopts α-helical conformations, than cholesterol-enriched LUVs mimicking mammalian cells. Thus, as bacteria present varied physiological features that favor antibiotic-resistance, Pa-MAP 1.9 could be a promising candidate in the development of tools against infections caused by pathogenic bacteria.
dc.identifier.citationCARDOSO, Marlon H. et al. A polyalanine peptide derived from polar fish with anti-infectious activities. Scientific Reports, London, v. 6, e21385, 2016. DOI: 10.1038/srep21385. Disponível em: https://www.nature.com/articles/srep21385. Acesso em: 16 fev. 2024.
dc.identifier.doi10.1038/srep21385
dc.identifier.issne- 2045-2322
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/24479
dc.language.isoeng
dc.publisher.countryGra-bretanha
dc.publisher.departmentInstituto de Química - IQ (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleA polyalanine peptide derived from polar fish with anti-infectious activities
dc.typeArtigo

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