A polyalanine peptide derived from polar fish with anti-infectious activities
dc.creator | Cardoso, Marlon Henrique e Silva | |
dc.creator | Ribeiro, Suzana Meira | |
dc.creator | Silva, Diego Oliveira Nolasco da | |
dc.creator | Fuente Nunez, César de la | |
dc.creator | Felício, Mário Romão | |
dc.creator | Gonçalves, Sónia | |
dc.creator | Matos, Carolina Oliveira | |
dc.creator | Liao, Luciano Morais | |
dc.creator | Santos, Nuno C. | |
dc.creator | Franco, Octavio Luiz | |
dc.creator | Migliolo, Ludovico | |
dc.creator | Hancock, Robert E. W. | |
dc.date.accessioned | 2024-03-07T13:19:42Z | |
dc.date.available | 2024-03-07T13:19:42Z | |
dc.date.issued | 2016-02-26 | |
dc.description.abstract | Due to the growing concern about antibiotic-resistant microbial infections, increasing support has been given to new drug discovery programs. A promising alternative to counter bacterial infections includes the antimicrobial peptides (AMPs), which have emerged as model molecules for rational design strategies. Here we focused on the study of Pa-MAP 1.9, a rationally designed AMP derived from the polar fish Pleuronectes americanus. Pa-MAP 1.9 was active against Gram-negative planktonic bacteria and biofilms, without being cytotoxic to mammalian cells. By using AFM, leakage assays, CD spectroscopy and in silico tools, we found that Pa-MAP 1.9 may be acting both on intracellular targets and on the bacterial surface, also being more efficient at interacting with anionic LUVs mimicking Gram-negative bacterial surface, where this peptide adopts α-helical conformations, than cholesterol-enriched LUVs mimicking mammalian cells. Thus, as bacteria present varied physiological features that favor antibiotic-resistance, Pa-MAP 1.9 could be a promising candidate in the development of tools against infections caused by pathogenic bacteria. | |
dc.identifier.citation | CARDOSO, Marlon H. et al. A polyalanine peptide derived from polar fish with anti-infectious activities. Scientific Reports, London, v. 6, e21385, 2016. DOI: 10.1038/srep21385. Disponível em: https://www.nature.com/articles/srep21385. Acesso em: 16 fev. 2024. | |
dc.identifier.doi | 10.1038/srep21385 | |
dc.identifier.issn | e- 2045-2322 | |
dc.identifier.uri | http://repositorio.bc.ufg.br//handle/ri/24479 | |
dc.language.iso | eng | |
dc.publisher.country | Gra-bretanha | |
dc.publisher.department | Instituto de Química - IQ (RMG) | |
dc.rights | Acesso Aberto | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | A polyalanine peptide derived from polar fish with anti-infectious activities | |
dc.type | Artigo |
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