Comparative proteomics in the three major human pathogenic species of the genus Sporothrix

Página do item simplificado
dc.creatorBailão, Mirelle Garcia Silva
dc.creatorLima, Patrícia de Sousa
dc.creatorOliveira, Manoel Marques Evangelista
dc.creatorOliveira, Luã Cardoso
dc.creatorPaes, Rodrigo Almeida
dc.creatorBorges, Clayton Luiz
dc.creatorBailão, Alexandre Melo
dc.creatorCoelho, Alexandre Siqueira Guedes
dc.creatorSoares, Célia Maria de Almeida
dc.creatorOliveira, Rosely Maria Zancopé
dc.date.accessioned2024-08-16T12:36:42Z
dc.date.available2024-08-16T12:36:42Z
dc.date.issued2021
dc.description.abstractSporotrichosis is a subcutaneous mycosis of humans and other mammals, caused by dimorphic species of the genus Sporothrix. In Brazil, human disease is broadly linked to transmission by infected cats and is mainly caused by Sporothrix brasiliensis, Sporothrix schenckii and Sporothrix globosa. In this study, we used a nanoscale liquid chromatography coupled with tandem mass spectrometry approach to provide the yeast proteomic profiles of S. brasiliensis, S. schenckii and S. globosa. From a total of 247 identified proteins, 137 were found as differentially expressed. Functional classification revealed that most are related to carbohydrate and amino acid metabolism as well as stress response. Our data indicate that S. brasiliensis metabolism is distinct of that of S. schenckii and S. globosa, mainly regarding amino acid metabolism and cell wall remodeling, which are induced in the former. Enzymes belonging to glycolytic pathway are, on the other hand, up-regulated in S. schenckii and S. globosa. These findings may explain the previously described more virulent character of S. brasiliensis. Besides complementing genomic comparisons already published, this first comparative proteomic study provided information that indicates new aspects of Sporothrix species metabolism as well as offers information that may be useful in the development of prospective functional studies.
dc.identifier.citationSILVA-BAILÃO, Mirelle Garcia et al. Comparative proteomics in the three major human pathogenic species of the genus Sporothrix. Microbes and Infection, Amsterdam, v. 20, e104762, 2021. DOI: 10.1016/j.micinf.2020.09.008. Disponível em: https://www.sciencedirect.com/science/article/pii/S1286457920301611. Acesso em: 8 ago. 2024.
dc.identifier.doi10.1016/j.micinf.2020.09.008
dc.identifier.issn1286-4579
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/25294
dc.language.isoeng
dc.publisher.countryHolanda
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectProteome
dc.subjectNanoscale liquid chromatography
dc.subjectMass spectrometry
dc.subjectSporothrix
dc.titleComparative proteomics in the three major human pathogenic species of the genus Sporothrix
dc.typeArtigo

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
Artigo - Mirelle Garcia Silva Bailão - 2021.pdf
Tamanho:
1.16 MB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

ICB - Artigos publicados em periódicos