Genotoxic and mutagenic effects of Atrazine Atanor 50 SC on Dendropsophus minutus Peters, 1872 (Anura: Hylidae) developmental larval stages

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dc.creatorGonçalves, Macks Wendhell
dc.creatorCampos, Calebe Bertolino Marins de
dc.creatorBatista, Vinícius Guerra
dc.creatorCruz, Aparecido Divino da
dc.creatorMarco Júnior, Paulo De
dc.creatorBastos, Rogério Pereira
dc.creatorSilva, Daniela de Melo e
dc.date.accessioned2023-08-10T13:24:26Z
dc.date.available2023-08-10T13:24:26Z
dc.date.issued2017
dc.description.abstractThe potential mutagenic and genotoxic effects of the herbicide atrazine were investigated in different developmental stages of Dendropsophus minutus tadpoles. These animals were exposed to 4 nominal concentrations of atrazine (2.25, 4.5, 9, and 18 mg/L) and 40 mg/L of Cyclophosphamide as a positive control, for 96 h. Negative controls were also added to the experiment. The tadpoles were divided into three groups according to Gosner's developmental stages, namely GS 25-33 as premetamorphic, GS 36-39 as prometamorphic, and GS 42-43 as metamorphic climax. Our results showed that the premetamorphic and metamorphic stages were more sensitive than the prometamorphic stage to the herbicide. A comet assay and micronucleus test for the sensitive stages demonstrated DNA damage in a concentration-dependent curve. Although a dose-response effect was not observed for the prometamorphic stage, a statistically significant difference was found between the treatment of 18 mg/L and the negative control. Moreover, the highest concentration of atrazine showed both the largest amount of DNA damage and the highest micronucleus frequency regardless of the developmental stage of D. minutus. In conclusion, atrazine was genotoxic and mutagenic for D. minutus in a dose-sensitive manner, dependent on larval developmental stages. Considering the prometamorphic stages showed no dose-response effect to atrazine, we suggest caution when using this stage in biomonitoring studies in order to avoid false negative results. Amphibians have been proven to be useful bioindicators, and we suggest replicating biomonitoring studies using different species to represent ecosystems' environmental impacts.pt_BR
dc.identifier.citationGONÇALVES, Macks Wendhell et al. Genotoxic and mutagenic effects of Atrazine Atanor 50 SC on Dendropsophus minutus Peters, 1872 (Anura: Hylidae) developmental larval stages. Chemosphere, Amsterdam, v. 182, p. 730-737, 2017. DOI: 10.1016/j.chemosphere.2017.05.078. Disponível em: https://www.sciencedirect.com/science/article/pii/S0045653517307828?via%3Dihub. Acesso em: 25 jul. 2023.pt_BR
dc.identifier.doi10.1016/j.chemosphere.2017.05.078
dc.identifier.issne- 1879-1298
dc.identifier.issn0045-6535
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0045653517307828?via%3Dihub
dc.language.isoengpt_BR
dc.publisher.countryHolandapt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RMG)pt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectHerbicidept_BR
dc.subjectTadpolept_BR
dc.subjectSusceptibilitypt_BR
dc.subjectGenotoxicitypt_BR
dc.subjectMutagenicitypt_BR
dc.titleGenotoxic and mutagenic effects of Atrazine Atanor 50 SC on Dendropsophus minutus Peters, 1872 (Anura: Hylidae) developmental larval stagespt_BR
dc.typeArtigopt_BR

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