Cardiac Chagas disease: MMPs, TIMPs, galectins, and TGF- β as tissue remodelling players

Página do item simplificado
dc.creatorCosta, Arthur Wilson Florencio da
dc.creatorCarmo Neto, José Rodrigues do
dc.creatorBraga, Yarlla Loyane Lira
dc.creatorSilva, Beatriz Aquino
dc.creatorLamounier, Amanda Borges
dc.creatorSilva, Bárbara Oliveira
dc.creatorReis, Marlene Antonia dos
dc.creatorOliveira, Flávia Aparecida de
dc.creatorCeles, Mara Rúbia Nunes
dc.creatorSilva, Juliana Reis Machado e
dc.date.accessioned2025-02-10T13:12:36Z
dc.date.available2025-02-10T13:12:36Z
dc.date.issued2019
dc.description.abstractA century after the discovery of Chagas disease, studies are still needed to establish the complex pathophysiology of this disease. However, it is known that several proteins and molecules are related to the establishment of this disease, its evolution, and the appearance of its different clinical forms. Metalloproteinases and their tissue inhibitors, galectins, and TGF-β are involved in the process of infection and consequently the development of myocarditis, tissue remodeling, and fibrosis upon infection with Trypanosoma cruzi. Thus, considering that the heart is one of the main target organs in Chagas disease, knowledge regarding the mechanisms of action of these molecules is essential to understand how they interact and trigger local and systemic reactions and, consequently, determine whether they contribute to the development of Chagas’ heart disease. In this sense, it is believed that the inflammatory microenvironment caused by the infection alters the expression of these proteins favoring progression of the host-parasite cycle and thereby stimulating cardiac tissue remodeling mechanisms and fibrosis. The aim of this review was to gather information on metalloproteinases and their tissue inhibitors, galectins, and TGF-β and discuss how these molecules and their different interrelationships contribute to the development of Chagas’ heart disease.
dc.identifier.citationCOSTA, Arthur Wilson Florencio da et al. Cardiac Chagas disease: MMPs, TIMPs, galectins, and TGF- β as tissue remodelling players. Disease Markers, New York, v. 2019, e3632906, 2019. DOI: 10.1155/2019/3632906. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2019/3632906. Acesso em: 6 fev. 2025.
dc.identifier.doi10.1155/2019/3632906
dc.identifier.issn0278-0240
dc.identifier.issne- 1875-8630
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/26630
dc.language.isoeng
dc.publisher.countryEstados unidos
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleCardiac Chagas disease: MMPs, TIMPs, galectins, and TGF- β as tissue remodelling players
dc.typeArtigo

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
Artigo - Arthur Wilson Florencio da Costa - 2019.pdf
Tamanho:
488.84 KB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

IPTSP - Artigos publicados em periódicos