Multichannel AC biosusceptometry system to map biodistribution and assess the pharmacokinetic profile of magnetic nanoparticles by imaging

Resumo

In this paper, the application of a technique to evaluate in vivo biodistribution of magnetic nanoparticles (MNP) is addressed: the Multichannel AC Biosusceptometry System (MC-ACB). It allows real-time assessment of magnetic nanoparticles in both bloodstream clearance and liver accumulation, where a complex network of inter-related cells is responsible for MNP uptake. Based on the acquired MC-ACB images, we propose a mathematical model which helps to understand the distribution and accumulation pharmacokinetics of MNP. The MC-ACB showed a high time resolution to detect and monitor MNP, providing sequential images over the particle biodistribution. Utilizing the MC-ACB instrument, we assessed regions corresponding to the heart and liver, and we determined the MNP transfer rates between the bloodstream and the liver. The pharmacokinetic model resulted in having a strong correlation with the experimental data, suggesting that the MC-ACB is a valuable and accessible imaging device to assess in vivo and real-time pharmacokinetic features of MNP.

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Citação

SOARES, Guilherme A. et al. Multichannel AC biosusceptometry system to map biodistribution and assess the pharmacokinetic profile of magnetic nanoparticles by imaging. IEEE Transactions on Nanobioscience, Piscataway, v. 18, n. 3, p. 456-462, 2019. DOI: 10.1109/TNB.2019.2912073. Disponível em: https://ieeexplore.ieee.org/document/8693876. Acesso em: 12 set. 2023.