Short-term social memory deficits in adult female mice exposed to tannery effluent and possible mechanism of action

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dc.creatorResende, Fernanda Neves Estrela
dc.creatorRabelo, Letícia Martins
dc.creatorVaz, Boniek Gontijo
dc.creatorCosta, Denys Ribeiro de Oliveira
dc.creatorSilva, Igor Pereira da
dc.creatorRodrigues, Aline Sueli de Lima
dc.creatorPinto, Guilherme Malafaia
dc.date.accessioned2023-08-04T15:04:48Z
dc.date.available2023-08-04T15:04:48Z
dc.date.issued2017
dc.description.abstractThe accumulated organic residues in tannery-plant courtyards are an eating attraction to small rodents; however, the contact of these animals with these residues may change their social behavior. Thus, the aim of the present study is to investigate whether the exposure to tannery effluent (TE) can damage the social recognition memory of female Swiss mice, as well as to assess whether vitamin C supplementation could provide information about how TE constituents can damage these animals’ memory. We have observed that resident females exposed to TE (without vitamin supplementation) did not explore the anogenital region, their body or chased intruding females for shorter time or with lower frequency during the retest session of the social recognition test, fact that indicates social recognition memory deficit in these animals. Such finding is reinforced by the confirmation that there was no change in the animals’ olfactory function during the buried food test, or locomotor changes in females exposed to the pollutant. Since no behavioral change was observed in the females exposed to TE and treated with vitamin C (before or after the exposure), it is possible saying that these social cognitive impairments seem to be directly related to the imbalance between the cellular production of reactive oxygen species and the counteracting antioxidant mechanisms (oxidative stress) in female mice exposed to the pollutant (without vitamin supplementation). Therefore, the present study evidences that the direct contact with tannery effluent, even for a short period-of-time, may cause short-term social memory deficits in adult female Swiss mice.pt_BR
dc.identifier.citationESTRELA, Fernanda Neves et al. Short-term social memory deficits in adult female mice exposed to tannery effluent and possible mechanism of action. Chemosphere, Amsterdam, v. 184, p. 148-158, 2017. DOI: 10.1016/j.chemosphere.2017.05.174. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0045653517308883?via%3Dihub. Acesso em: 28 jun. 2023.pt_BR
dc.identifier.doi10.1016/j.chemosphere.2017.05.174
dc.identifier.issne- 1879-1298
dc.identifier.issn0045-6535
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0045653517308883?via%3Dihub
dc.language.isoengpt_BR
dc.publisher.countryHolandapt_BR
dc.publisher.departmentInstituto de Química - IQ (RMG)pt_BR
dc.rightsAcesso Restritopt_BR
dc.titleShort-term social memory deficits in adult female mice exposed to tannery effluent and possible mechanism of actionpt_BR
dc.typeArtigopt_BR

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