Anxiolytic-like effect of 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol is mediated through the benzodiazepine and nicotinic pathways

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dc.creatorBrito, Adriane Ferreira de
dc.creatorFajemiroye, James Oluwagbamigbe
dc.creatorNeri, Hiasmin Franciely da Silva
dc.creatorSilva, Dayane Moreira da
dc.creatorSilva, Daiany Priscilla Bueno da
dc.creatorSanz Lobón, Germán
dc.creatorVaz, Boniek Gontijo
dc.creatorCarvalho, Flávio Silva de
dc.creatorGhedini, Paulo César
dc.creatorLiao, Luciano Morais
dc.creatorMenegatti, Ricardo
dc.creatorCosta, Elson Alves
dc.date.accessioned2023-08-03T15:33:48Z
dc.date.available2023-08-03T15:33:48Z
dc.date.issued2017
dc.description.abstractIn this study, we proposed the design, synthesis of a new compound 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol (LQFM032), and pharmacological evaluation of its anxiolytic-like effect. This new compound was subjected to pharmacological screening referred to as Irwin test, prior to sodium pentobarbital-induced sleep, open-field and wire tests. The anxiolytic-like effect of this compound was evaluated using elevated plus maze and light–dark box tests. In addition, the mnemonic activity was evaluated through step-down test. In sodium pentobarbital-induced sleep test, LQFM032 decreased latency and increased duration of sleep. In the open-field test, LQFM032 altered behavioral parameter, that suggested anxiolytic-like activity, as increased in crossings and time spent at the center of open field. In the plus maze test and light–dark box test, the LQFM032 showed anxiolytic-like activity, increased entries and time spent on open arms, and increased in number of transitions and time spent on light area, respectively. Those effects was antagonized by flumazenil but not with 1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazine (NAN-190). The LQFM032 did not alter mnemonic activity. Moreover, the anxiolytic-like activity of LQFM032 was antagonized by mecamylamine. In summary, LQFM032 showed benzodiazepine and nicotinic pathways mediated anxiolytic-like activity without altering the mnemonic activity.pt_BR
dc.identifier.citationBRITO, Adriane F. et al. Anxiolytic-like effect of 2-(4-((1-Phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol is mediated through the benzodiazepine and nicotinic pathways. Chemical Biology & Drug Design, [s. l.], v. 90, n. 3, p. 432-442, 2017. DOI: 10.1111/cbdd.12961. Disponível em: https://onlinelibrary.wiley.com/doi/epdf/10.1111/cbdd.12961. Acesso em: 28 jun. 2023.pt_BR
dc.identifier.doi10.1111/cbdd.12961
dc.identifier.issne- 1747-0285
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/cbdd.12961
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Química - IQ (RMG)pt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectbenzodiazepine sitept_BR
dc.subjectLQFM032pt_BR
dc.subjectNicotinic activitypt_BR
dc.subjectPiperazine derivativept_BR
dc.titleAnxiolytic-like effect of 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol is mediated through the benzodiazepine and nicotinic pathwayspt_BR
dc.typeArtigopt_BR

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