Host protein biomarkers identify active tuberculosis in HIV uninfected and co-infected individuals

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dc.creatorAchkar, Jacqueline M.
dc.creatorCortes, Laetitia
dc.creatorCroteau, Pascal
dc.creatorYanofsky, Corey
dc.creatorMentinova, Marija
dc.creatorRajotte, Isabelle
dc.creatorSchirm, Michael
dc.creatorZhouc, Yiyong
dc.creatorKipnis, Ana Paula Junqueira
dc.creatorKasprowicz, Victoria O.
dc.creatorLarsen, Michelle
dc.creatorAllard, René
dc.creatorHunter, Joanna
dc.creatorParamithiotis, Eustache
dc.date.accessioned2018-10-25T13:15:54Z
dc.date.available2018-10-25T13:15:54Z
dc.date.issued2015
dc.description.abstractBiomarkers for active tuberculosis (TB) are urgently needed to improve rapid TB diagnosis. The objective of this study was to identify serum protein expression changes associated with TB but not latent Mycobacterium tuberculosis infection (LTBI), uninfected states, or respiratory diseases other than TB (ORD). Serum samples from 209 HIV uninfected (HIV−) and co-infected (HIV+) individuals were studied. In the discovery phase samples were analyzed via liquid chromatography and mass spectrometry, and in the verification phase biologically independent samples were analyzed via a multiplex multiple reaction monitoring mass spectrometry (MRM-MS) assay. Compared to LTBI and ORD, host proteins were significantly differentially expressed in TB, and involved in the immune response, tissue repair, and lipid metabolism. Biomarker panels whose composition differed according to HIV status, and consisted of 8 host proteins in HIV− individuals (CD14, SEPP1, SELL, TNXB, LUM, PEPD, QSOX1, COMP, APOC1), or 10 host proteins in HIV+ individuals (CD14, SEPP1, PGLYRP2, PFN1, VASN, CPN2, TAGLN2, IGFBP6), respectively, distinguished TB from ORD with excellent accuracy (AUC=0.96 for HIV− TB, 0.95 for HIV+ TB). These results warrant validation in larger studies but provide promise that host protein biomarkers could be the basis for a rapid, blood-based test for TB.pt_BR
dc.identifier.citationACHKAR, Jacqueline M. et.al. Host protein biomarkers identify active tuberculosis in HIV uninfected and co-infected individuals. EBioMedicine, Amsterdã, v. 2, p. 1160-1168, 2015.pt_BR
dc.identifier.doi10.1016/j.ebiom.2015.07.039
dc.identifier.issne- 2352-3964
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16240
dc.language.isoengpt_BR
dc.publisher.countryHolandapt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHost proteinspt_BR
dc.subjectTuberculosispt_BR
dc.subjectBiomarkerpt_BR
dc.subjectDiagnosticspt_BR
dc.titleHost protein biomarkers identify active tuberculosis in HIV uninfected and co-infected individualspt_BR
dc.typeArtigopt_BR

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