Cardiovascular adjustments induced by hypertonic saline in hemorrhagic rats: involvement of carotid body chemoreceptors

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dc.creatorPedrino, Gustavo Rodrigues
dc.creatorRossi, Marcio Vinícius
dc.creatorSchoorlemmer, Guus H. M.
dc.creatorLopes, Oswaldo Ubriaco
dc.creatorCravo, Sergio Luiz Domingues
dc.date.accessioned2021-01-15T14:09:17Z
dc.date.available2021-01-15T14:09:17Z
dc.date.issued2011
dc.description.abstractThe peripheral hyperosmolarity elicited by intravenous infusion of hypertonic saline brings potential benefits to the treatment of hemorrhage. The neural mechanisms involved in these beneficial effects remain unknown. The present study examines the role of carotid chemoreceptors in cardiovascular responses induced by hypertonic saline after hypovolemic hemorrhage in rats. Male Wistar rats (300–400 g) were anesthetized with thiopental, and instrumented for recording of mean arterial pressure. Arterial pressure was reduced to 60 mmHg by withdrawal of arterial blood over 10 min, and maintained at this level for 60 min by withdrawal or infusion of blood. In control rats (n=8) with intact chemoreceptors, the subsequent intravenous infusion of hypertonic saline (3 M NaCl, 1.8 ml kg−1 body weight, in 2 min) restored blood pressure (pressure increased from 61±4 to 118±5 mm Hg). In experimental rats (n=8), the carotid body arteries were tied, 30 min after the beginning of the hypotensive phase, leaving the carotid chemoreceptors ischemic. In these rats, hypertonic saline failed to restore blood pressure (pressure increased from 55±1 to 70±6 mm Hg). These findings suggest that the restoration of blood pressure after hypovolemic hemorrhage induced by hypertonic saline depends on intact carotid chemoreceptors.pt_BR
dc.identifier.citationPEDRINO, Gustavo R. et al. Cardiovascular adjustments induced by hypertonic saline in hemorrhagic rats: involvement of carotid body chemoreceptors. Autonomic Neuroscience: basic & clinical, Amsterdam, v. 160, p. 37-41, 2011.pt_BR
dc.identifier.issn1566-0702
dc.identifier.issne- 1872-7484
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/19297
dc.language.isoengpt_BR
dc.publisher.countryHolandapt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHypovolemic hemorrhagept_BR
dc.subjectArterial blood pressure and heart ratept_BR
dc.subjectHypertonic salinept_BR
dc.titleCardiovascular adjustments induced by hypertonic saline in hemorrhagic rats: involvement of carotid body chemoreceptorspt_BR
dc.typeArtigopt_BR

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