Nitazoxanide induces in vitro metabolic acidosis in Taenia crassiceps cysticerci
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Data
2016
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Resumo
Nitazoxanide (NTZ) is a broad-spectrum anti-parasitic drug used against a wide variety of protozoans
and helminthes. Albendazole, its active metabolite albendazole sulfoxide (ABZSO), is one of the drugs of
choice to treat both intestinal and tissue helminth and protozoan infections. However little is known
regarding their impact on the metabolism of parasites. The aim of this study was to compare the in vitro
effect of NTZ and ABZSO in the glycolysis of Taenia crassiceps cysticerci. The cysticerci were treated with
1.2; 0.6; 0.3 or 0.15 mg/mL of NTZ or ABZSO. Chromatographic and spectrophotometric analyses were
performed in the culture medium and in the cysticerci extract. Regarding the glucose concentrations was
possible to observe two responses: impair of the uptake and gluconeogenesis. The pyruvate concentrations were increased in the ABZSO treated group. Lactate concentrations were increased in the culture
medium of NTZ treated groups. Therefore it was possible to infer that the metabolic acidosis was greater
in the group treated with NTZ than in the ABZSO treated group indicating that this is one of the modes of
action used by this drug to induce the parasite death.
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Nitazoxanide, Albendazole sulfoxide, Anaerobic metabolism, Lactic acid, Taenia crassiceps
Citação
ISAC, Eliana et al. Nitazoxanide induces in vitro metabolic acidosis in Taenia crassiceps cysticerci. Experimental Parasitology, Orlando, v. 171, p. 17-22, 2016. DOI: 10.1016/j.exppara.2016.10.012. Disponível em: https://www.sciencedirect.com/science/article/pii/S001448941630248X?via%3Dihub. Acesso em: 24 fev. 2025.