Nitazoxanide induces in vitro metabolic acidosis in Taenia crassiceps cysticerci

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dc.creatorIsac, Eliana
dc.creatorPicanço, Guaraciara de Andrade
dc.creatorCosta, Tatiane Luiza da
dc.creatorLima, Nayana Ferreira de
dc.creatorAlves, Daniella de Sousa Mendes Moreira
dc.creatorFraga, Carolina Miguel
dc.creatorLino Junior, Ruy de Souza
dc.creatorVinaud, Marina Clare
dc.date.accessioned2025-02-28T11:37:06Z
dc.date.available2025-02-28T11:37:06Z
dc.date.issued2016
dc.description.abstractNitazoxanide (NTZ) is a broad-spectrum anti-parasitic drug used against a wide variety of protozoans and helminthes. Albendazole, its active metabolite albendazole sulfoxide (ABZSO), is one of the drugs of choice to treat both intestinal and tissue helminth and protozoan infections. However little is known regarding their impact on the metabolism of parasites. The aim of this study was to compare the in vitro effect of NTZ and ABZSO in the glycolysis of Taenia crassiceps cysticerci. The cysticerci were treated with 1.2; 0.6; 0.3 or 0.15 mg/mL of NTZ or ABZSO. Chromatographic and spectrophotometric analyses were performed in the culture medium and in the cysticerci extract. Regarding the glucose concentrations was possible to observe two responses: impair of the uptake and gluconeogenesis. The pyruvate concentrations were increased in the ABZSO treated group. Lactate concentrations were increased in the culture medium of NTZ treated groups. Therefore it was possible to infer that the metabolic acidosis was greater in the group treated with NTZ than in the ABZSO treated group indicating that this is one of the modes of action used by this drug to induce the parasite death.
dc.identifier.citationISAC, Eliana et al. Nitazoxanide induces in vitro metabolic acidosis in Taenia crassiceps cysticerci. Experimental Parasitology, Orlando, v. 171, p. 17-22, 2016. DOI: 10.1016/j.exppara.2016.10.012. Disponível em: https://www.sciencedirect.com/science/article/pii/S001448941630248X?via%3Dihub. Acesso em: 24 fev. 2025.
dc.identifier.doi10.1016/j.exppara.2016.10.012
dc.identifier.issn0014-4894
dc.identifier.issne- 1090-2449
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/26789
dc.language.isoeng
dc.publisher.countryEstados unidos
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNitazoxanide
dc.subjectAlbendazole sulfoxide
dc.subjectAnaerobic metabolism
dc.subjectLactic acid
dc.subjectTaenia crassiceps
dc.titleNitazoxanide induces in vitro metabolic acidosis in Taenia crassiceps cysticerci
dc.typeArtigo

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