Chemical composition and antifungal activity of the essential Oil of hyptis ovalifolia benth

Resumo

The leaves of Hyptis ovalifolia Benth. (Lamiaceae) were subjected to hydrodistillation and the resulting volatiles were investigated by GC/MS. The main constituent representing 60% of the essential oil was isolated by column chromatography and identified by spectroscopic methods as (R)-6-[(Z)-1-heptenyl]-5,6-dihydro-2H-pyran-2-one (1). This compound showed strong in vitro activity against four dermatophyte fungi Microsporum canis, Microsporum gypseum, Tricophyton mentagrophytes, and Tricophyton rubrum (a total of 60 strains) with a minimal inhibitory concentration observed in the range of 125-7.8 μg mL-1.

Descrição

Palavras-chave

Hyptis ovalifolia, Essential oil, Antifungal activity, Lamiaceae, (R)-6-[(Z)-1-heptenyl]- 5,6-dihydro-2H-pyran-2-one

Citação

OLIVEIRA, Cecília . M. A de et al. Chemical composition and antifungal activity of the essential oil of hyptis ovalifolia benth. (Lamiaceae). Journal of the Brazilian Chemical Society, Campinas, v. 15, n. 5, p. 756-759, 2004.