Chalcone derivatives: promising starting points for drug design
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2017
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Resumo
Medicinal chemists continue to be fascinated by chalcone derivatives because of their
simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a variety
of promising biological activities. However, chalcones have still not garnered deserved attention,
especially considering their high potential as chemical sources for designing and developing new
effective drugs. In this review, we summarize current methodological developments towards the
design and synthesis of new chalcone derivatives and state-of-the-art medicinal chemistry strategies
(bioisosterism, molecular hybridization, and pro-drug design). We also highlight the applicability
of computer-assisted drug design approaches to chalcones and address how this may contribute to
optimizing research outputs and lead to more successful and cost-effective drug discovery endeavors.
Lastly, we present successful examples of the use of chalcones and suggest possible solutions to
existing limitations.
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Natural products, Chalcone derivatives, Chalcone synthesis, Molecular modification strategies, Computer-assisted drug design
Citação
GOMES, Marcelo N. et al. Chalcone derivatives: promising starting points for drug design. Molecules, Basel, v. 22, n. 8, e1210, 2017. DOI: 10.3390/molecules22081210. Disponível em: https://www.mdpi.com/1420-3049/22/8/1210. Acesso em: 28 fev. 2025.