Wound healing and anti-inflammatory effect in animal models of Calendula officinalis L. growing in Brazil
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2012
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Calendula officinalis is an annual herb from Mediterranean origin which is popularly used in wound healing and as an anti-
inflammatory agent. In this study, the ethanolic extract, the dichloromethane, and hexanic fractions of the flowers from plants
growing in Brazil were produced. The angiogenic activity of the extract and fractions was evaluated through the chorioallantoic
membrane and cutaneous wounds in rat models. The healing activity of the extract was evaluated by the same cutaneous wounds
model through macroscopic, morphometric, histopathologic, and immunohistochemical analysis. The antibacterial activity of
the extract and fractions was also evaluated. This experimental study revealed that C. officinalis presented anti-inflammatory
and antibacterial activities as well as angiogenic and fibroplastic properties acting in a positive way on the inflammatory and
proliferative phases of the healing process.
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PARENTE, Leila Maria Leal et al . Wound healing and anti-inflammatory effect in animal models of Calendula officinalis L. growing in Brazil. Evidence-Based Complementary and Alternative Medicine, London, v. 2012, p. 1-7, 2012.