Desorption electrospray ionization imaging for neurotransmitters evaluation: a potential approach to Parkinson’s disease monitoring
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2023
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Resumo
Parkinson’s disease (PD) is globally known as the
most common movement disorder and the second
most common neurodegenerative disease. The
disease includes the symptoms of involuntary limb
tremors, stiffness, or inflexibility of limbs and joints,
among others. Due to this, scientific reports on
analytical methodologies to evaluate the
progression of neurodegenerative diseases are
extremely necessary. Traditional methods include
histochemical, immunohistochemical, and ligandbased approaches, however, these approaches
still suffer from selectivity limitations of association,
leading to a wrong evaluation. In this context,
mass spectrometry imaging methods, such as
desorption electrospray ionization (DESI), are
potential approaches to visualize the distribution of
biomarkers that can lead to the information on the progress of PD. This review aims to bring a discussion
of some DESI methodologies reported in the literature for the assessment of neurotransmitters associated
with PD.
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Amino acids, DESI-imaging, Mass spectrometry, Neurotransmitters, Parkinson’s disease
Citação
MACIEL, Lanaia Ítala Louzeiro et al. Desorption electrospray ionization imaging for neurotransmitters evaluation: a potential approach to Parkinson’s disease monitoring. Brazilian Journal of Analytical Chemistry, Campinas, v. 10, n. 38, p. 18-34, 2022. DOI: 10.30744/brjac.2179-3425.RV-42-2022. Disponível em: https://brjac.com.br/artigos/brjac-42-2022.pdf. Acesso em: 17 maio 2023.