The effect of folic acid supplementation with ferrous sulfate on the linear and ponderal growth of children aged 6–24 months: a randomized controlled trial
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2015-02
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BACKGROUND/OBJECTIVES: Studies evaluating the effect of folic acid supplementation, either alone or in combination with iron,
on the linear and ponderal growth of children are practically nonexistent. The aim of this study was to assess the effect of folic acid
supplementation with ferrous sulfate on both linear growth and weight gain in anemic and nonanemic children attending
Municipal Daycare Centers in Goiania, State of Goias, Brazil.
SUBJECTS/METHODS: A double-blind, randomized, controlled trial was conducted on 188 children aged 6–24 months. The effects
of ferrous sulfate and folic acid supplementation were evaluated using the analysis of variance procedure, based on a double
factorial model with two factors of fixed effects (folic acid supplementation and ferrous sulfate supplementation), adjusted for initial
weight. The level of significance was 0.05.
RESULTS: The children who received folic acid supplementation showed greater weight gain than the monthly average
weight gain of those not given the supplement (P = 0.026). This effect was independent of the dose of ferrous sulfate (P for
interaction = 0.693). Folic acid supplementation increased the gain of weight-for-age Z-score when compared with the placebo
group (P = 0.018), independent of the dose of ferrous sulfate.
CONCLUSION: Folic acid had no effect on linear growth. The use of folic acid supplementation increased the monthly average
weight gain and the gain in weight-for-age Z-score compared with the placebo group. This effect was independent of the dose of
ferrous sulfate.
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MEDEIROS, D. A. et al. The effect of folic acid supplementation with ferrous sulfate on the linear and ponderal growth of children aged 6-24 months: a randomized controlled trial. European Journal of Clinical Nutrition, London, v. 69, n. 2, p. 198-204, Feb. 2015.