Manganese ferrite-based nanoparticles induce ex vivo, but not in vivo, cardiovascular effects
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Data
2014
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Resumo
Magnetic nanoparticles (MNPs) have been used for various biomedical applications.
Importantly, manganese ferrite-based nanoparticles have useful magnetic resonance imaging
characteristics and potential for hyperthermia treatment, but their effects in the cardiovascular
system are poorly reported. Thus, the objectives of this study were to determine the cardiovascular
effects of three different types of manganese ferrite-based magnetic nanoparticles: citrate-coated
(CiMNPs); tripolyphosphate-coated (PhMNPs); and bare magnetic nanoparticles (BaMNPs).
The samples were characterized by vibrating sample magnetometer, X-ray diffraction, dynamic
light scattering, and transmission electron microscopy. The direct effects of the MNPs on cardiac
contractility were evaluated in isolated perfused rat hearts. The CiMNPs, but not PhMNPs and
BaMNPs, induced a transient decrease in the left ventricular end-systolic pressure. The PhMNPs
and BaMNPs, but not CiMNPs, induced an increase in left ventricular end-diastolic pressure,
which resulted in a decrease in a left ventricular end developed pressure. Indeed, PhMNPs and
BaMNPs also caused a decrease in the maximal rate of left ventricular pressure rise (+dP/dt)
and maximal rate of left ventricular pressure decline (-dP/dt). The three MNPs studied induced
an increase in the perfusion pressure of isolated hearts. BaMNPs, but not PhMNPs or CiMNPs,
induced a slight vasorelaxant effect in the isolated aortic rings. None of the MNPs were able to
change heart rate or arterial blood pressure in conscious rats. In summary, although the MNPs
were able to induce effects ex vivo, no significant changes were observed in vivo. Thus, given
the proper dosages, these MNPs should be considered for possible therapeutic applications.
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Cardiac function, Isolated heart, Magnetic fluids, Magnetic nanoparticles, Nanomedicine
Citação
NUNES, Allancer D. C.; RAMALHO, Laylla S.; SOUZA, Álvaro P. S.; MENDES, Elisabeth P.; COLUGNATI, Diego B.; ZUFELATO, Nícholas; SOUSA, Marcelo H.; BAKUZIS, Andris F.; CASTRO, Carlos H. Manganese ferrite-based nanoparticles induce ex vivo, but not in vivo, cardiovascular effects. International Journal of Nanomedicine, Macclesfield, v. 9, n. 1, p. 3299-3312, 2014.