Estudo clínico nos olhos dos cães, tratados com 2-1 fosfato dissódico de betametasona e fosfato dissódico/acetato de dexametasona, que receberam implantes com córneas de suínos

Abstract

asone Di&,odic Fosphate and Dissodic Fosphate/ Acetate Dexamethasone Ten mixed beed dogs, with a 10 kg average weight, were selected at Centro de Zoonoses de Goiânia. After being examined and considered healthy the dogs were enumerated from 11 to 20 on their collars. Each animal had swine comea implanted into the left eye. The swine comea was obtained at Casa de Banha Caçula, a slaughterhouse, and conserved in humid charnber for a maximum 6 hour period. Before surgery, each animal received 4 mg dissodic fosphate/acetate dexamethasone IM and was instilled one drop ofbetamethasone dissodic fosphate and one drop of gentamicin sulphate, maintaining the ocular medication once 4 times/day and the intramuscular medication once a week, until enthanasia. After xenografts being realized, each comea was examined every 7 days using direct ophthalmoscope to analyse transparency, vessels new formation, episcleral and conjunctival vessels reation, cornea thickness, depth and presence or absence of deposits into the anterior chamber. On day 7 clinicai evaluation, ali comea xenotransplant eyes (100%) had lost transparency (++,+++), there was episcleral vessels reaction (P), anterior chamber depth was preserved (N), there wasn't edema, as well as deposits (A) on anterior chamber. On day 14, with the loss oftwo corneas by "self-trauma", lhe other dogs had their implanted comeas (80%) completely opaque (+++), with important ciliary reaction (P), edema (A); however, the anterior chamber integrity was preserved (N), without presence of deposits (A). With three more dogs euthaniz.ed between days 14 and 21. due to corticosteroids side-effects. the remaining dogs (50%) preserved their implants with the day 14 alterations until the cnd of this experience.