Copper(I) selenophene-2-carboxylate (CuSC) promoted C–S cross-coupling reaction of thiols with aryl iodides
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2019
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We reported the synthesis of copper (I)-selenophene-2-carboxylate (CuSC) and application as new catalyst in the cross-coupling reactions of thiols with aryl iodide to afford the corresponding unsymmetrical thioethers. The optimized reaction conditions were applied to thiols and aryl iodides having a wide range of functional groups, including electron rich and electron poor substrates. The chemoselectivity of the reaction with 4-iodobromobenzene and 2-aminothiophenol derivatives was briefly examined through the competitive iodine versus bromine and thiol versus nitrogen cross-coupling.
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Unsymmetrical thioethers, Copper(I) carboxylate, Crosscoupling, Chemoselectivity, Regioselectivity
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BARROS, Olga Soares do Rêgo; SILVA, Francielle Rodrigues; NUNES, Vanessa Loren. Copper(I) selenophene-2-carboxylate (CuSC) promoted C-S cross-coupling reaction of thiols with aryl iodides. Journal of Sulfur Chemistry, London, v. 40, n. 1, p. 9-17, 2019. DOI: 10.1080/17415993.2018.1519566. Disponível em: https://www.tandfonline.com/doi/full/10.1080/17415993.2018.1519566. Acesso em: 05 jul. 2024.