Structural analysis of two tetraketones and theoretical investigation of the reactions involved in their preparation

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dc.creatorSilva, Milene Lopes da
dc.creatorTeixeira, Róbson Ricardo
dc.creatorSantos, Lucas de Azevedo
dc.creatorMartins, Felipe Terra
dc.creatorRamalho, Teodorico de Castro
dc.date.accessioned2023-11-30T11:20:53Z
dc.date.available2023-11-30T11:20:53Z
dc.date.issued2018
dc.description.abstractThe 2,2'-((5-(4-bromophenyl)furan-2-yl)methylene) bis (5,5-dimethylcyclohexane-1,3-dione) (3) and 2,2'-((5-(4-chlorophenyl)furan-2-yl)methylene) bis (5,5-dimethylcyclohexane-1,3-dione) (4) were prepared in, respectively, 63% and 59% yield, via ZrOCl2⋅8H2O catalyzed condensation reactions between dimedone and appropriate aldehydes. Their structures were investigated by IR, NMR, and X-ray spectroscopy techniques. The asymmetric unit of tetraketone 3 is composed of just one molecule, while two almost identical crystallographically independent molecules of compound 4 are present there. Compound 3 is conformationally similar to both molecules of 4. The diketone rings assume a half-chair conformation with the flaps oriented toward the same side of the substituent at C1. Each diketone ring is featured by an electronic delocalization path encompassed through the keto-enol moiety. All bond lengths inside this conjugated system are intermediate between those of pure double and single bonds. Furthermore, the furan plane of the substituent at C1 is almost parallel to the bond axes bridging the diketone rings as a consequence of steric hindrance effects between the heterocycle moiety and two hydrogen bonded oxygens. The enol forms of compounds 3 and 4 were noticed via IR and NMR spectroscopies. Furthermore, thermodynamics parameters were calculated in order to interpret the experimental results. In this line, theoretical findings reveal that electronic and solvent effects play an important role in the chemical reactions involved in the preparation of tetraketones.
dc.identifier.citationSILVA, Milene Lopes da et al. Structural analysis of two tetraketones and theoretical investigation of the reactions involved in their preparation. Journal of Molecular Structure, Amsterdam, v. 1156, p. 700-711, 2018. DOI: 10.1016/j.molstruc.2017.11.105. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0022286017315934?via%3Dihub. Acesso em: 29 nov. 2023.
dc.identifier.doi10.1016/j.molstruc.2017.11.105
dc.identifier.issne- 1872-8014
dc.identifier.issn0022-2860
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0022286017315934?via%3Dihub
dc.language.isoeng
dc.publisher.countryHolanda
dc.publisher.departmentInstituto de Química - IQ (RMG)
dc.rightsAcesso Restrito
dc.subjectTetraketones
dc.subjectX-ray analysis
dc.subjectDFT calculations
dc.subjectZirconium
dc.subjectKeto-enol tautomerism
dc.titleStructural analysis of two tetraketones and theoretical investigation of the reactions involved in their preparation
dc.typeArtigo

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