Trypanosoma cruzi infection and/or administration of the nonsteroidal anti-inflammatory nimesulide increase the number of colonic crypts overexpressing metallothioneins in rat colon carcinogenesis

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dc.creatorEscalante, Rodrigo Dornfeld
dc.creatorOliveira, Enio Chaves de
dc.creatorCunha, F. Q.
dc.creatorVespĂșcio, Marcelo VinĂ­cius Oliveira
dc.creatorSilva, Alfredo Ribeiro da
dc.creatorAprilli, Francisco
dc.creatorGarcia, S. B.
dc.date.accessioned2019-02-06T11:28:44Z
dc.date.available2019-02-06T11:28:44Z
dc.date.issued2006
dc.description.abstractTrypanosoma cruzi infection and nonsteroidal anti-inflammatory drugs inhibit colorectal carcinogenesis by mechanisms not completely known and metallothionein proteins (MTs) may be involved in this process. Sixty-six male Wistar rats weighing 90 to 120 g were randomly divided into seven groups (GI to GVII). GI, GII and GIII animals were subcutaneously infected with 200,000 trypomastigote forms of the Y strain of T. cruzi. After 8 weeks, GI, GII, GIV, and GVI were injected with one weekly subcutaneous dose of 12 mg/kg dimethylhydrazine for 4 weeks. In sequence, GI, GIV and GV were treated with nimesulide (10 mg/kg per dose, five times per week for 8 weeks). Groups I, III, IV, and VI had 12 animals, and each of the other groups had 6 animals. All the animals were euthanized 8 weeks after the last dimethylhydrazine injection. The colons were fixed and processed for MT immunohisto- chemistry. The index of MT-overexpressing colonic crypts (MTEC) was estimated as the percentage of MT-stained crypts in relation to the total number of crypts scored. Five hundred crypts per animal were scored. Data were analyzed by the Kruskal-Wallis test followed by the Dunn test. There was an increase in MTEC index in the groups either infected with T. cruzi or treated with nimesulide or both infected and treated when compared to control (401, 809, and 1011%, respective- ly). We suggest that the increased formation of MTEC may be related to the protection against carcinogenesis provided both by T. cruzi infection and nimesulide.pt_BR
dc.identifier.citationESCALANTE, R. D. et al. Trypanosoma cruzi infection and/or administration of the nonsteroidal anti-inflammatory nimesulide increase the number of colonic crypts overexpressing metallothioneins in rat colon carcinogenesis. Brazilian Journal of Medical and Biological Research, RibeirĂŁo Preto, v. 39, n. 7, p. 895-899, 2006.pt_BR
dc.identifier.doi10.1590/S0100-879X2006000700007
dc.identifier.issn0100-879
dc.identifier.issne- 1414-431X
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16984
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFaculdade de Medicina - FM (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectTrypanosoma cruzipt_BR
dc.subjectDimethylhydrazinept_BR
dc.subjectMetallothioneinspt_BR
dc.subjectColon carcinogenesispt_BR
dc.subjectNimesulidept_BR
dc.titleTrypanosoma cruzi infection and/or administration of the nonsteroidal anti-inflammatory nimesulide increase the number of colonic crypts overexpressing metallothioneins in rat colon carcinogenesispt_BR
dc.typeArtigopt_BR

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