Insights into Histoplasma capsulatum behavior on zinc deprivation

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dc.creatorAssunção, Leandro do Prado
dc.creatorMoraes, Dayane
dc.creatorSoares, Lucas Weba
dc.creatorBailão, Mirelle Garcia Silva
dc.creatorSiqueira, Janaina Gomes de
dc.creatorBaeza, Lilian Cristiane
dc.creatorBáo, Sônia Nair
dc.creatorSoares, Célia Maria de Almeida
dc.creatorBailão, Alexandre Melo
dc.date.accessioned2024-08-16T12:41:16Z
dc.date.available2024-08-16T12:41:16Z
dc.date.issued2020
dc.description.abstractHistoplasma capsulatum is a thermodimorphic fungus that causes histoplasmosis, a mycosis of global incidence. The disease is prevalent in temperate and tropical regions such as North America, South America, Europe, and Asia. It is known that during infection macrophages restrict Zn availability to H. capsulatum as a microbicidal mechanism. In this way the present work aimed to study the response of H. capsulatum to zinc deprivation. In silico analyses showed that H. capsulatum has eight genes related to zinc homeostasis ranging from transcription factors to CDF and ZIP family transporters. The transcriptional levels of ZAP1, ZRT1, and ZRT2 were induced under zinc-limiting conditions. The decrease in Zn availability increases fungicidal macrophage activity. Proteomics analysis during zinc deprivation at 24 and 48 h showed 265 proteins differentially expressed at 24 h and 68 at 48 h. Proteins related to energy production pathways, oxidative stress, and cell wall remodeling were regulated. The data also suggested that low metal availability increases the chitin and glycan content in fungal cell wall that results in smoother cell surface. Metal restriction also induces oxidative stress triggered, at least in part, by reduction in pyridoxin synthesis.
dc.identifier.citationASSUNÇÃO, Leandro do Prado et al. Insights into Histoplasma capsulatum behavior on zinc deprivation. Frontiers in Cellular and Infection Microbiology, Lausanne, v. 10, e573097, 2020. DOI: 10.3389/fcimb.2020.573097. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734293/. Acesso em: 8 ago. 2024.
dc.identifier.doi10.3389/fcimb.2020.573097
dc.identifier.issn2235-2988
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/25295
dc.language.isoeng
dc.publisher.countrySuica
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectFungal pathogenesis
dc.subjectZn uptake
dc.subjectZn and cell wall remodeling
dc.subjectProteomics
dc.subjectZinc homeostasis
dc.titleInsights into Histoplasma capsulatum behavior on zinc deprivation
dc.typeArtigo

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