In vivo magnetic nanoparticle hyperthermia: a review on preclinical studies, low-field nano-heaters, noninvasive thermometry and computer simulations for treatment planning
Nenhuma Miniatura disponível
Data
2020
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Magnetic nanoparticle hyperthermia (MNH) is a promising nanotechnology-based cancer thermal therapy
that has been approved for clinical use, together with radiation therapy, for treating brain tumors.
Almost ten years after approval, few new clinical applications had appeared, perhaps because it cannot
benefit from the gold standard noninvasive MRI thermometry technique, since static magnetic
fields inhibit heat generation. This might limit its clinical use, in particular as a single therapeutic
modality. In this article, we review the in vivo MNH preclinical studies, discussing results of the last
two decades with emphasis on safety as a clinical criteria, the need for low-field nano-heaters and
noninvasive thermal dosimetry, and the state of the art of computational modeling for treatment planning
using MNH. Limitations to more effective clinical use are discussed, together with suggestions for
future directions, such as the development of ultrasound-based, computed tomography-based or magnetic
nanoparticle-based thermometry to achieve greater impact on clinical translation of MNH.
Descrição
Palavras-chave
Thermal nanomedicine, Multicore nanoparticles, Bioheat equation, Computational modeling, Cancer, Thermal dose
Citação
RODRIGUES, Harley F.; CAPISTRANO, Gustavo; BAKUZIS, Andris F. In vivo magnetic nanoparticle hyperthermia: a review on preclinical studies, low-field nano-heaters, noninvasive thermometry and computer simulations for treatment planning. International Journal of Hyperthermia, London, v. 37, n. 3, p. 76-99, 2020. DOI: 10.1080/02656736.2020.1800831. Disponível em: https://www-tandfonline.ez49.periodicos.capes.gov.br/doi/full/10.1080/02656736.2020.1800831. Acesso em: 11 abr. 2023.