Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes

Santos Neto, José Sebastião dos; Balaguez, Renata Azevedo; Franco, Marcelo Straesser; Machado, Victor Cordova de Sá; Saba, Sumbal; Khan, Jamal Rafique; Galetto, Fábio Zazyki; Braga, Antonio Luiz

Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes

Data

2020

Autores

Santos Neto, José Sebastião dos

Balaguez, Renata Azevedo

Franco, Marcelo Straesser

Machado, Victor Cordova de Sá

Saba, Sumbal

Khan, Jamal Rafique

Galetto, Fábio Zazyki

Braga, Antonio Luiz

Resumo

Herein, we describe an efficient, rapid and benign protocol for the direct C(sp2)–H bond halogenation (Cl, Br, I) of 2-arylimidazo[1,2-a]pyridines using trihaloisocyanuric acids in ethanol. Furthermore, this sustainable protocol was successfully extended to imidazopyrimidine, imidazothiazole and indazole heterocycles showing the broadness of this useful approach.

Citação

SANTOS NETO, José Sebastião et al. Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of Imidazo-heteroarenes. Green Chemistry, [s. l.], v. 22, n. 11, p. 3410-3415, 2020. DOI: 10.1039/D0GC00137F. Disponível em: https://pubs.rsc.org/en/content/articlelanding/2020/gc/d0gc00137f. Acesso em: 31 jul. 2024.