Antimicrobial alumina nanobiostructures of disulfide- and triazole-linked peptides: synthesis, characterization, membrane interactions and biological activity

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dc.creatorTorres, Lívia Mara Fontes Costa
dc.creatorAlmeida, Mainara Trindade de
dc.creatorSantos, Talita Lopes dos
dc.creatorMarinho, Luiz Eduardo Silva
dc.creatorMesquita, João Paulo de
dc.creatorSilva, Leonardo Morais da
dc.creatorSantos, Wallans Torres Pio dos
dc.creatorMartins, Helen Rodrigues
dc.creatorKato, Kelly Cristina
dc.creatorAlves, Eliane Santana Fernandes
dc.creatorLiao, Luciano Morais
dc.creatorMagalhães, Mariana Torquato
dc.creatorMendonça, Fernanda Gomes de Quezado de
dc.creatorPereira, Fabiano Vargas
dc.creatorResende, Jarbas Magalhães
dc.creatorBemquerer, Marcelo Porto
dc.creatorRodrigues, Magali Aparecida
dc.creatorVerly , Rodrigo Moreira
dc.date.accessioned2024-02-08T11:09:41Z
dc.date.available2024-02-08T11:09:41Z
dc.date.issued2019
dc.description.abstractDue to the its physical-chemical properties, alumina nanoparticles have potential applications in several areas, such as nanobiomaterials for medicinal or orthodontic implants, although the introduction of these devices poses a serious risk of microbial infection. One convenient strategy to circumvent this problem is to associate the nanomaterials to antimicrobial peptides with broad-spectrum of activities. In this study we present two novel synthesis approaches to obtain fibrous type alumina nanoparticles covalently bound to antimicrobial peptides. In the first strategy, thiol functionalized alumina nanoparticles were linked via disulfide bond formation to a cysteine residue of an analog of the peptide BP100 containing a four amino acid spacer (Cys-Ala-Ala-Ala). In the second strategy, alumina nanoparticles were functionalized with azide groups and then bound to alkyne-decorated analogs of the peptides BP100 and DD K through a triazole linkage obtained via a copper(I)-catalyzed cycloaddition reaction. The complete physical-chemical characterization of the intermediates and final materials is presented along with in vitro biological assays and membrane interaction studies, which confirmed the activity of the obtained nanobiostructures against both bacteria and fungi. To our knowledge, this is the first report of aluminum nanoparticles covalently bound to triazole-peptides and to a disulfide bound antimicrobial peptide with high potential for biotechnological applications.
dc.identifier.citationTORRES, L. M. F. C. et al. Antimicrobial alumina nanobiostructures of disulfide- and triazole-linked peptides: synthesis, characterization, membrane interactions and biological activity. Colloids and Surfaces B: biointerfaces, Amsterdam, v. 177, p. 94-104, 2019. DOI: 10.1016/j.indcrop.2018.12.045. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0927776519300529?via%3Dihub. Acesso em: 29 jan. 2024.
dc.identifier.doi10.1016/j.indcrop.2018.12.045
dc.identifier.issn0927-7765
dc.identifier.issne- 1873-4367
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0927776519300529?via%3Dihub
dc.language.isoeng
dc.publisher.countryHolanda
dc.publisher.departmentInstituto de Química - IQ (RMG)
dc.rightsAcesso Restrito
dc.titleAntimicrobial alumina nanobiostructures of disulfide- and triazole-linked peptides: synthesis, characterization, membrane interactions and biological activity
dc.typeArtigo

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