Amperometric folic acid quantification using a supramolecular tetraruthenated nickel porphyrin µ-peroxo-bridged matrix modified electrode associated to batch injection analysis

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dc.creatorFerreira, Luís Marcos Cerdeira
dc.creatorMartins, Paulo Roberto
dc.creatorAraki, Koiti
dc.creatorToma, Henrique Eisi
dc.creatorAngnes, Lucio
dc.date.accessioned2024-07-19T08:24:31Z
dc.date.available2024-07-19T08:24:31Z
dc.date.issued2015
dc.description.abstractA supramolecular Nickel (II) porphyrin complex containing four pyridyl-bis(2,2′-bipyridyl)chloro ruthenium meso substituents was submitted to successive voltammetric cycles in high alkaline media to produce a supramolecular matrix with Nickel centers linked by µ-peroxo bridges, producing a highly stable thin film able to act as redox mediator for electrocatalytic oxidation of folic acid. The characterization of electrode surface material was performed by Scanning Electron Microscopy and Electrochemical Impedance Spectroscopy. The modified electrode was inserted into a batch injection electrochemical cell used for the rapid and precise quantification of folic acid in pharmaceutical products. The favorable hydrodynamic conditions provided by amperometry-BIA association allowed a very high throughput with good linear range (1 to 200 µmol L−1) and low detection limit (7.37×10−7 mol L−1). The electrochemical method was applied to the quantification of folic acid in different tablet samples. The results were comparable with values indicated by the manufacturer and those found using high HPLC according to the Brazilian Pharmacopoeia; commercial samples were submitted to a procedure in order to remove lactose of tablets, since carbohydrates act as interfering species. This procedure together with the electrochemical method showed to be simple, rapid, efficient and an appropriate alternative for quantifying this compound in real samples.
dc.identifier.citationFERREIRA, Luís M. C. et al. Amperometric folic acid quantification using a supramolecular tetraruthenated nickel porphyrin µ-peroxo-bridged matrix modified electrode associated to batch injection analysis. Electroanalysis, Weinheim, v. 27, n. 10, p. 2322-2328, 2015. DOI: 10.1002/elan.201500251. Disponível em: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/elan.201500251. Acesso em: 5 jul. 2024.
dc.identifier.doi10.1002/elan.201500251
dc.identifier.issn1040-0397
dc.identifier.issne- 1521-4109
dc.identifier.urihttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/elan.201500251
dc.language.isoeng
dc.publisher.countryAlemanha
dc.publisher.departmentInstituto de Química - IQ (RMG)
dc.rightsAcesso Restrito
dc.subjectNickel tetraruthenated porphyrin
dc.subjectModified electrode
dc.subjectFolic acid
dc.subjectBIA-amperometry
dc.subjectPharmaceutical analysis
dc.titleAmperometric folic acid quantification using a supramolecular tetraruthenated nickel porphyrin µ-peroxo-bridged matrix modified electrode associated to batch injection analysis
dc.typeArtigo

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