Exploring cellular uptake of iron oxide nanoparticles associated with rhodium citrate in breast cancer cells

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dc.creatorChaves, Natalia Lemos
dc.creatorEstrela-Lopis, Irina
dc.creatorBöttner, Julia
dc.creatorLopes, Cláudio Afonso Pinho
dc.creatorGuido, Bruna Cândido
dc.creatorSouza, Aparecido Ribeiro de
dc.creatorBáo, Sônia Nair
dc.date.accessioned2023-06-21T11:18:34Z
dc.date.available2023-06-21T11:18:34Z
dc.date.issued2017-08-02
dc.description.abstractNanocarriers have the potential to improve the therapeutic index of currently available drugs by improving their efficacy and achieving therapeutic steady-state levels over an extended period. The association of maghemite–rhodium citrate (MRC) nanoparticles (NPs) has the potential to increase specificity of the cytotoxic action. However, the interaction of these NPs with cells, their uptake mechanism, and subcellular localization need to be elucidated. This work evaluates the uptake mechanism of MRC NPs in metastatic and nonmetastatic breast cancer-cell models, comparing them to a nontumor cell line. MRC NPs uptake in breast cancer cells was more effective than in normal cells, with regard to both the amount of internalized material and the achievement of more strategic intracellular distribution. Moreover, this process occurred through a clathrin-dependent endocytosis pathway with different basal expression levels of this protein in the cell lines tested.pt_BR
dc.identifier.citationCHAVES, Natalia L. et al. Exploring cellular uptake of iron oxide nanoparticles associated with rhodium citrate in breast cancer cells. International Journal of Nanomedicine, London, v. 12, p. 5511-5523, 2017. DOI: 10.2147/IJN.S141582. Disponível em: https://www.dovepress.com/exploring-cellular-uptake-of-iron-oxide-nanoparticles-associated-with--peer-reviewed-fulltext-article-IJN. Acesso em: 16 jun. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.2147/IJN.S141582
dc.identifier.issn1176-9114
dc.identifier.issne- 1178-2013
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/22752
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentInstituto de Química - IQ (RMG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMaghemitept_BR
dc.subjectNanomaterialspt_BR
dc.subjectCells uptakept_BR
dc.subjectEndocytosispt_BR
dc.titleExploring cellular uptake of iron oxide nanoparticles associated with rhodium citrate in breast cancer cellspt_BR
dc.typeArtigopt_BR

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