In vitro and in silico analysis reveals antifungal activity and potential targets of curcumin on Paracoccidioides spp.

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dc.creatorRocha, Olívia Basso
dc.creatorSilva, Lívia do Carmo
dc.creatorCarvalho Júnior, Marcos Antonio Batista de
dc.creatorOliveira, Amanda Alves de
dc.creatorSoares, Célia Maria de Almeida
dc.creatorPereira, Maristela
dc.date.accessioned2024-11-28T13:31:27Z
dc.date.available2024-11-28T13:31:27Z
dc.date.issued2021
dc.description.abstractThe search for new compounds with activity against Paracoccidioides, etiologic agents of Paracoccidioidomycosis (PCM), is extremely necessary due to the current scenario of the available therapeutic arsenal. Treatment is restricted to three classes of antifungals with side effects. Curcumin is a polyphenol with antifungal effects that is extracted from Curcuma longa. The present work aimed to evaluate the activity of curcumin in different species of Paracoccidioides and to evaluate the potential molecular targets of curcumin using computational strategies. In addition, interactions with classic antifungals used in the treatment of PCM were evaluated. Curcumin inhibits the growth of Paracoccidioides spp. exerting a fungicidal effect. The combination of curcumin with amphotericin B, co-trimoxazole, and itraconazole showed a synergistic or additive interaction. Molecular targets as superoxide dismutase, catalase, and isocitrate lyase were proposed based on in silico approaches. Curcumin affects the fungal plasma membrane and increases the production of reactive oxygen species. Therefore, curcumin is a good alternative for the treatment of PCM.
dc.identifier.citationROCHA, Olívia Basso et al. In vitro and in silico analysis reveals antifungal activity and potential targets of curcumin on Paracoccidioides spp. Brazilian Journal of Microbiology, Rio de Janeiro, v. 52, p. 1897–1911, 2021. DOI: 10.1007/s42770-021-00548-6. Disponível em: https://link.springer.com/article/10.1007/s42770-021-00548-6. Acesso em: 21 nov. 2024.
dc.identifier.doi10.1007/s42770-021-00548-6
dc.identifier.issn1517-8382
dc.identifier.issne- 1678-4405
dc.identifier.urihttps://link.springer.com/article/10.1007/s42770-021-00548-6
dc.language.isoeng
dc.publisher.countryBrasil
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RMG)
dc.rightsAcesso Restrito
dc.titleIn vitro and in silico analysis reveals antifungal activity and potential targets of curcumin on Paracoccidioides spp.
dc.typeArtigo

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