Effects of ethanolic extract of leaves of Lafoensia pacari A. St.-Hil., Lythraceae (pacari), in pain and inflammation models
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2010-07
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Resumo
Lafoensia pacari A. St.-Hil., Lythraceae, popularly known as pacari, is a Cerrado’s
native specimen; the stem bark extract is used in folk for pain and inflammation, also showing
sedating activity. This study aimed to evaluate the analgesic and anti inflammatory activities of
ethanol extract from pacari leaves (EEPL). These activities were verified in mice. The previous
treatment with EEPL 1.0 g/kg showed antinociceptive activity both in the acetic acid-induced
writing test and in the formalin-induced model of pain, and in neurogenic and inflammatory phases
as well. In the croton oil-induced ear edema, the pre-treatments with EEPL reduced the edema
in a dose-dependent manner. Also in the carrageenan-induced peritonitis, the two major doses
tested (2.0 and 1.5 g/kg p.o.) were able to reduce the leukocyte migration in a dose-dependent
manner. The Central Nervous System tests showed that the extract does not elicit uncoordinated
motricity, hypnosis or sedating effects. The results showed that EEPL maintains the analgesic and
anti-inflammatory effects of the stem bark of pacari, being the collect of leaves more favorable to
the preservation of this Cerrado’s native specimen.
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Dor, Lythraceae, Extrato das folhas, Lafoensia pacari, Inflamação, Pain, Inflammation, Leaf extract, Lafoensia pacari, Lythraceae
Citação
GUIMARÃES, Heloisa Alves et al. Effects of ethanolic extract of leaves of Lafoensia pacari A. St.-Hil., Lythraceae (pacari), in pain and inflammation models. Revista Brasileira de Farmacognosia, Curitiba, v. 20, n. 3, p. 328-333, June/July 2010.