Vascular calcifications seen on mammography: an independent factor indicating coronary artery disease
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Data
2009
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Resumo
PURPOSE: Establish a relationship between vascular calcifications seen via mammography and coronary artery disease, estimate
the risk ratios, and investigate the interrelationships between vascular calcification and other risk factors for coronary artery disease.
MATERIALS AND METHODS: This was a case-control study consisting of 40 women with coronary artery disease in the case
group and 40 women without any history of coronary artery disease in the control group who were matched according to age. The
study was approved by the Institution’s Research Ethics Committee (consent statement was obtained). Odds ratios and confidence
intervals were calculated using univariate analysis. Interrelationships among other risk factors, such as arterial hypertension, dys-
lipidemia, smoking and diabetes mellitus, were calculated using multivariate analysis. A p <0.05 was considered to be significant
for statistical analysis.
RESULTS: The mean ages for the case and control groups were 64.65 years and 63.88 years, respectively. In multivariate analy-
sis, the only variables related to coronary artery disease were Vascular calcification [OR 4.71 (CI 1.36-16.33) p=0.014], family
history [OR 5.76 (CI 1.58-21.03) p=0.008] and arterial hypertension [OR 15.92 (CI 3.12-81.14) p=0.001]. Although smoking and
diabetes are important variables in the pathogenesis of coronary artery disease, these factors did not show statistically significant
associations in this sample.
CONCLUSION: The presence of vascular calcifications seen via mammography was an independent risk factor for coronary artery
disease, as were hypertension and a family history of coronary artery disease.
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Palavras-chave
Mammography, Coronary artery disease, Vascular calcifications
Citação
OLIVEIRA, Evelling L. C. et al. Vascular calcifications seen on mammography: an independent factor indicating coronary artery disease. Clinics, São Paulo, v. 64, n. 8, p. 763-767, 2009.