Mechanisms of copper and zinc homeostasis in pathogenic black fungi

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dc.creatorBailão, Mirelle Garcia Silva
dc.creatorSilva, Kassyo Lobato Potenciano da
dc.creatorAnjos, Laura Raniere Borges dos
dc.creatorLima, Patrícia de Sousa
dc.creatorTeixeira, Marcus de Melo
dc.creatorSoares, Célia Maria de Almeida
dc.creatorBailão, Alexandre Melo
dc.date.accessioned2024-08-16T13:36:06Z
dc.date.available2024-08-16T13:36:06Z
dc.date.issued2018
dc.description.abstractBlack fungi comprise a diverse group of melanized microorganisms, many of which are able to infect humans. One of the recognized diseases that arise with black fungi infection is chromoblastomycosis, a neglected implantation mycosis. Considering their ecology, black fungi may face conditions with distinct metal availability. Zinc and copper are essential transition metals, which become toxic in excess. During the interaction with host, fungi may face either metal deprivation or poisoning. Here we report an in silico analysis of four black fungi genomes concerning zinc and copper homeostasis. Overall, these organisms share apparatus of metal uptake, storage and detoxification with other pathogenic and non-pathogenic fungi. Genes coding plasma membrane and organelle transporters, as well as metal binding proteins were identified. Althought putatives zinc and copper responsive transcription factors have been found in the analyzed genomes, remarkable structural differences were perceived when compared to the already characterized regulators. Black fungi may harbor unique features concerning the regulation of zinc and copper homeostasis, which is probably a result of the niches they can inhabit. The data provided here add knowlegde to a still unexplored aspect of black fungi biology that may be useful in the understanding of their pathogenicity.
dc.identifier.citationSILVA-BAILÃO, Mirelle Garcia et al. Mechanisms of copper and zinc homeostasis in pathogenic black fungi. Fungal Biology, Amsterdam, v. 122, n. 6, p. 526-537, 2017. DOI: 10.1016/j.funbio.2017.12.002. Disponível em: https://www.sciencedirect.com/science/article/pii/S1878614617301678. Acesso em: 9 ago. 2024.
dc.identifier.doi10.1016/j.funbio.2017.12.002
dc.identifier.issn1878-6146
dc.identifier.issne- 1878-6162
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1878614617301678
dc.language.isoeng
dc.publisher.countryHolanda
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RMG)
dc.rightsAcesso Restrito
dc.subjectBlack fungus pathogenesis
dc.subjectChromoblastomycosis
dc.subjectFungal virulence
dc.subjectMetal sensing
dc.titleMechanisms of copper and zinc homeostasis in pathogenic black fungi
dc.typeArtigo

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