A avaliação da segurança e eficácia clínica de uma solução líquida de éter gliceril guaiacol pronta para uso (EGG-PPU) em cavalos

Abstract

The main objective of this study was to evaluate the clinical efficiency and safety of a 10% GGE solution ready to use (EGG-PPU) after intravenous injection in horses. The compatibility of the EGG-PPU solution with xylazine and ketamine and its cardiorespiratory effects were also evaluated. Four equines received the conventional GGE solution prepared just before the use (EGG group), after 21 days the animals received the EGG-PPU solution (PPU group), and after a new period of 21 days the equines received the EGG-PPU solution associated with ketamine and xyazine (TD group). Heart and respiratory rates, pulse oxymetry, meand arterial pressures and rectal temperature were evaluated. The time of administration of the solutions; the latency for recumbency; the time between the end of the administration of the solutions and the sternal recumbency; and the time between the end of the administration of solutions and the quadrupedal position were registered. Finally it was presented the EGG-PPU formulation developed for anesthesia of large animals, as well as its clinical efficiency and pharmacological evaluation. We concluded that the EGG-PPU solution is efficient and safe for chemical restraint of horses and is compatible with ketamine and xylazine for intravenous anesthesia in this species.