Nitrogen catabolite repression in members of Paracoccidioides complex

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dc.creatorLeite, Vanessa Rafaela Milhomem Cruz
dc.creatorFurlaneto, Silvia Maria Salem Izacc
dc.creatorNovaes, Evandro
dc.creatorNeves, Bruno Junior
dc.creatorBrito, Wesley de Almeida
dc.creatorSilva, Lana OHara Souza
dc.creatorPaccez, Juliano Domiraci
dc.creatorRocha, Juliana Alves Parente
dc.creator Pereira, Maristela
dc.creatorSoares, Célia Maria de Almeida
dc.creatorBorges, Clayton Luiz
dc.date.accessioned2024-09-12T14:23:47Z
dc.date.available2024-09-12T14:23:47Z
dc.date.issued2020
dc.description.abstractParacoccidioides complex is a genus that comprises pathogenic fungi which are responsible by systemic disease Paracoccidioidomycosis. In host tissues, pathogenic fungi need to acquire nutrients in order to survive, making the uptake of nitrogen essential for their establishment and dissemination. Nitrogen utilization is employed by the alleviation of Nitrogen Catabolite Repression (NCR) which ensures the use of non-preferential or alternative nitrogen sources when preferential sources are not available. NCR is controlled by GATA transcription factors which act through GATA binding sites on promoter regions in NCR-sensitive genes. This process is responsible for encoding proteins involved with the scavenge, uptake and catabolism of a wide variety of non-preferential nitrogen sources. In this work, we predict the existence of AreA GATA transcription factor and feature the zinc finger domain by three-dimensional structure in Paracoccidioides. Furthermore, we demonstrate the putative genes involved with NCR response by means of in silico analysis. The gene expression profile under NCR conditions was evaluated. Demonstrating that P. lutzii supported transcriptional regulation and alleviated NCR in non-preferential nitrogen-dependent medium. The elucidation of NCR in members of Paracoccidioides complex will provide new knowledge about survival, dissemination and virulence for these pathogens with regard to nitrogen-scavenging strategies in the interactions of host-pathogens.
dc.identifier.citationCRUZ-LEITE, Vanessa Rafaela Milhomem et al. Nitrogen catabolite repression in members of Paracoccidioides complex. Microbial Pathogenesis, Amsterdam, v. 149, e104281, 2020. DOI: 10.1016/j.micpath.2020.104281. Disponível em: https://www.sciencedirect.com/science/article/pii/S0882401020306471. Acesso em: 9 set. 2024.
dc.identifier.doi10.1016/j.micpath.2020.104281
dc.identifier.issn0882-4010
dc.identifier.issne- 1096-1208
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0882401020306471
dc.language.isoeng
dc.publisher.countryHolanda
dc.publisher.departmentFaculdade de Farmácia - FF (RMG)
dc.rightsAcesso Restrito
dc.subjectNitrogen metabolism
dc.subjectParacoccidioides spp.
dc.subjectAreA GATA transcription factor
dc.subjectThree-dimensional structure
dc.subjectCharacterization
dc.titleNitrogen catabolite repression in members of Paracoccidioides complex
dc.typeArtigo

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