Qualitative and quantitative control of pediatric syrups using Nuclear Magnetic Resonance and chemometrics

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dc.creatorAlves Filho, Elenilson de Godoy
dc.creatorSilva, Lorena Mara Alexandre e
dc.creatorAraújo, Nathália Vitória Pereira
dc.creatorLiao, Luciano Morais
dc.creatorAlcantara, Glaucia Braz
dc.date.accessioned2024-02-06T14:35:29Z
dc.date.available2024-02-06T14:35:29Z
dc.date.issued2018
dc.description.abstractSeveral flavoring and sweetening agents added to excipient of pediatric syrups are not declared in the package leaflet. Therefore, the aim of this study was to develop a non-target, simple, and precise method for qualitative and quantitative evaluation of pediatric syrups using NMR spectroscopy combined with chemometrics. This approach allowed the identification of several added compounds as citric acid, cyclamate, ethanol, glycerol, propylene glycol, saccharin, sorbitol, fructose, glucose, and sucrose. Among the sugared syrups, sucrose was the main carbohydrate with approximately 59.1%, and for sweetened syrups, glycerol with 25.5%. The ethanol was found with highest concentration of 4.0%, approximately. In addition, some syrups presented both sugar and sweetener, which is inconsistent according to the purpose of the addition. Consequently, institutional structures of countries as Brazil that are in charge of public health should put additional compliance pressure on pharmaceutical companies to clearly declare in package leaflet the presence and exact amount of the main compounds (at least) existent in the pediatric excipients.
dc.identifier.citationALVES FILHO, Elenilson G. et al. Qualitative and quantitative control of pediatric syrups using Nuclear Magnetic Resonance and chemometrics. Journal of Pharmaceutical and Biomedical Analysis, Amsterdam, v. 153, p. 29-36, 2018. DOI: 10.1016/j.jpba.2018.02.013. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0731708517331102?via%3Dihub. Acesso em: 29 jan. 2024.
dc.identifier.doi10.1016/j.jpba.2018.02.013
dc.identifier.issn0731-7085
dc.identifier.issne- 1873-264X
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0731708517331102?via%3Dihub
dc.language.isoeng
dc.publisher.countryHolanda
dc.publisher.departmentInstituto de Química - IQ (RMG)
dc.rightsAcesso Restrito
dc.titleQualitative and quantitative control of pediatric syrups using Nuclear Magnetic Resonance and chemometrics
dc.typeArtigo

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