The C57BL/6J mice offspring originated from a parental generation exposed to tannery effluents shows object recognition deficits
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2016-09-13
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The main aim of the present paper is to assess whether the parental generation exposure to such discharges could cause object recognition deficits in their offspring. Male and female C57Bl/6J mice were
put to mate after they were exposed to 7.5% and 15% tannery effluents or water (control group), for 60
days. The male mice were withdrawn from the boxes after 15 days and the female mice remained
exposed to the treatment during the gestation and lactation periods. The offspring were subjected to the
object recognition test after weaning in order to assess possible cognition losses. The results of the
analysis of the novel object recognition index found in the testing session (performed 1 h after the
training session) applied to offspring from different experimental groups appeared to be statistically
different. The novel object recognition index of the offspring from female mice exposed to tannery effluents (7.5% and 15% groups) was lower than that of the control group, and it demonstrated object
recognition deficit in the studied offspring. The present study is the first to report evidences that parental
exposure to effluent of tannery (father and mother) can cause object recognition deficit in the offspring,
which is related to problems in the central nervous system.
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Agro-industrial effluents, Experimental models, Xenobiotics, Toxicity
Citação
GUIMARÃES, Abraão Tiago Batista et al. The C57BL/6J mice offspring originated from a parental generation exposed to tannery effluents shows object recognition deficits. Chemosphere, Oxford, v. 164, p. 593-602, 2016. DOI: 10.1016/j.chemosphere.2016.08.144. Disponível em: https://www.sciencedirect.com/science/article/pii/S0045653516311894?via%3Dihub. Acesso em: 21 jun. 2023.