A randomized, controlled, crossover trial of oral midazolam and hydroxyzine for pediatric dental sedation
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Data
2003
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Resumo
The effectiveness of oral midazolam in pediatric dentistry is controversial. This randomized, controlled,
crossover, double blind clinical trial was conducted in order to study the effect of midazolam, used either alone or in
association with hydroxyzine, during child dental treatment. Thirty seven dental sedation sessions were carried out on
11 ASA I uncooperative children less than five years-old. In each appointment children were randomly assigned to
groups: P - placebo, M - midazolam (1.0 mg/kg), or MH - midazolam (0.75 mg/kg) plus hydroxyzine (2.0 mg/kg). Vital
signs (blood pressure, breathing rate, pulse and oxygen saturation) and behavior parameters (consciousness, crying,
movement, overall behavior) were evaluated every 15 minutes. Friedman and Wilcoxon statistical tests were used to
compare groups and different moments in the same group. Normal values of vital signs were usually registered. Heart
rate increased in groups P and M as the session went on. Group M presented less crying and movement at the first 15
minutes of treatment. Group MH caused more drowsiness at the beginning of the session. Overall behavior was better
in group M than in groups P or MH. Group M produced effective sedation in 77% of the cases, and group MH did so in
30.8%. It was concluded that midazolam was effective and safe, and its association with hydroxyzine did not lead to
additional advantages in pediatric dental sedation.
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Palavras-chave
Conscious sedation, Pediatric dentistry, Hydroxyzine, Sedação consciente, Hidroxizina, Odontopediatria
Citação
LIMA, Alessandra Rodrigues de Almeida; COSTA, Luciane Ribeiro de Rezende Sucasas da; COSTA, Paulo Sérgio Sucasas da. A randomized, controlled, crossover trial of oral midazolam and hydroxyzine for pediatric dental sedation. Pesquisa Odontológica Brasileira, São Paulo, v. 17, n. 3, p. 206-211, 2003.