Design, synthesis, antinociceptive and anti-inflammatory activities of novel piroxicam analogues

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dc.creatorMiranda, Amanda Silva de
dc.creatorBispo Júnior, Walfrido
dc.creatorSilva, Yolanda Karla Cupertino da
dc.creatorMoreira, Magna Suzana Alexandre
dc.creatorCastro, Rosane de Paula
dc.creatorSabino, José Ricardo
dc.creatorLião, Luciano Morais
dc.creatorLima, Lídia Moreira
dc.creatorBarreiro, Eliezer Jesus de Lacerda
dc.date.accessioned2018-07-12T15:51:27Z
dc.date.available2018-07-12T15:51:27Z
dc.date.issued2012
dc.description.abstractIn this paper we report the design, synthesis, antinociceptive and anti-inflammatory activities of a series of benzothiazine N-acylhydrazones 14a–h, planned by structural modification of piroxicam (1), a non steroidal anti-inflammatory drug. Among the synthesized analogues, compounds 14f (LASSBio-1637) and 14g (LASSBio-1639) were identified as novel antinociceptive and anti-inflammatory prototypes, active by oral administration, acting by a mechanism of action that seems to be different from that of piroxicam, since they were inactive as an inhibitor of cyclooxygenase (COX-1 and COX-2) at concentrations of 10 M.pt_BR
dc.identifier.citationMIRANDA, Amanda Silva de; BISPO JÚNIOR, Walfrido; SILVA, Yolanda Carla Cupertino da; ALEXANDRE-MOREIRA, Magna Suzana; CASTRO, Rosane de Paula; SABINO, José Ricardo; LIÃO, Luciano Morais; LIMA, Lídia Moreira; BARREIRO, Eliezer J. Design, synthesis, antinociceptive and anti-inflammatory activities of novel piroxicam analogues. Molecules, Basel, v. 17, p. 14126-14145, 2012.pt_BR
dc.identifier.doi10.3390/molecules171214126
dc.identifier.issne- 1420-3049
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15394
dc.language.isoengpt_BR
dc.publisher.countrySuicapt_BR
dc.publisher.departmentInstituto de Física - IF (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPiroxicampt_BR
dc.subjectInflammationpt_BR
dc.subjectPainpt_BR
dc.subjectAcylhydrazonept_BR
dc.subjectNSAIDpt_BR
dc.subjectCOXpt_BR
dc.titleDesign, synthesis, antinociceptive and anti-inflammatory activities of novel piroxicam analoguespt_BR
dc.typeArtigopt_BR

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