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Item AVALIAÇÃO DA TOXICIDADE PRÉ-CLINICA DO LÁTEX E DO EXTRATO ETANÓLICO DAS FOLHAS E DE Synadenium umbellatum PAX.(Universidade Federal de Goiás, 2008-03-12) AZEREDO, Flaubertt Santana de; CUNHA, Luiz Carlos da; http://lattes.cnpq.br/6349547031976679Item Avaliação da toxicidade oral aguda e atividade diurética de Celtis iguanaea (Jacq.) Sargent(Universidade Federal de Goiás, 2011-08-30) GONÇALVES, Nádyla Zanon; CUNHA, Luiz Carlos da; http://lattes.cnpq.br/6349547031976679Celtis iguanaea (Jacq.) Sargent is a species commonly known as cock-spur, in the Ulmaceae family and characterized as a shrub or small tree with branches long and very flexible. Is used for the treatment of urinary tract infections, kidney (kidney stones and pyelonephritis) and as a diuretic. Popular reports in the State of Goiás indicate the use of the spur cockscomb in the form of tea leaves. The aqueous extract of Celtis iguananea was tested in Wistar rats to assess single dose diuretic activity in observing the effect of same on urinary volume and products of metabolism (urea and creatinine) and assess the multiple-dose diuretic activity by observing the effect on the urinary volume and urinary excretion of electrolytes sodium (Na +) and potassium (K +), and also in Wistar rats and mice Swiss to test its acute oral toxicity following the Guide 423 (OECD), in which the animals were observed for 14 days after single administration of 2000mg/kg of extract, including this test the histopathological study of heart, lung, kidneys, liver, spleen, pancreas and intestines. The aqueous extract of cock-spur in their three doses (70, 200 and 600 mg/kg) did not submit multiple dose diuretic activity and only because it has not increased the excretion of water, electrolytes and metabolites of neither. The extract was framed in the class 5 (substance with Ld50 more than 2000 mg/kg and less than 5000 mg/kg), being considered of low toxicity, but histopathological findings cardiotoxicity and nephrotoxicity suggested does not extract any acute oral toxicity test (2000mg/kg), with an increase of absolut weight from the kidney and heart of male rats and mices treated with the extract and microscopic examination of kidney of male rats showing marked presence of cylinder hialinos no glomerulus.Item Motorização terapêutica do metotrexato sob altas doses, em pacientes portadores de leucemia linfoblástica aguda(Universidade Federal de Goiás, 2008-09-29) LELES, Raphael Nunes; CUNHA, Luiz Carlos da; http://lattes.cnpq.br/6349547031976679Methotrexate (MTX) is a drug with high toxicity, used in high doses for the treatment of neoplasic diseases. Therapeutic concentrations preserve the effectiveness, but higher values increases the toxicity risks. The aim of this article was to develop and validate an analytical method on HPLC-PDA to measure methotrexate plasma levels on children affected by LLA. The analytical method was performed with a mobile phase composed by acetic acid 0,1%:methanol:acetonitrile in concentration gradients during the analysis. The validation parameters were: specificity, relative recovery, lowest (LLQ) and higher limits of quantification, precision (Intra-assay standard deviation), accuracy, log time stability, calibration curve and co-validation. Biological samples were collected from 7 patients hospitalized on Araújo Jorge Hospital totaling 42 blood samples used to estimate the pharmacokinetic parameters. As results we obtained a method with a flow-rate of 1.5 mL/min, the methotrexate and teophyllin detection were observed in 304 and 271 nm respectively, in 13 minutes of carryover. The relative recovery was about 71%, LLQ about 0,1 μg/Ml. Intra-assay standard deviation was 11% for LLQ and no more than 14,88% for other concentrations; the accuracy was 97,63% and the long time stability was confirmed in human blood with a -20º C freezing. As pharmacokinetic parameters, we estimate the total clearance (3,03 L/h), constant of elimination (0,2586 h-1), a distribution volume of 12,57 L, half-life time as 2,73 h and median AUCT (for area under the time vs concentratrion curve) of 626,493 μgh/mL. As conclusion, the analytical method proved to be high efficient to detect and to quantify the drug on human blood, and we observed the high variability of the pharmacokinetic parameters, showing the importance of realize the therapeutic drug monitoring.Item Avaliação pré clínica da toxicidade aguda e da atividade diurética oral do extrato aquoso bruto das folhas da palicourea coriacea (cham.) k. Schum (Rubiaceae) douradinha do campo(Universidade Federal de Goiás, 2011-08-29) PEREIRA, Marcelo Elias; CUNHA, Luiz Carlos da; http://lattes.cnpq.br/6349547031976679Palicourea coriacea (Cham.) K. Schum, known as douradinha or douradinha-docampo, is a plant of Cerrado in the form of sub-shrubs with yellow flowers, belonging to the Rubiaceae family. Its leaves are used in preparations of home remedies in the form of teas, to treat kidney stones, inflammation / infection of the urethra, kidneys, bladder, and as a diuretic. This study aimed to evaluate the acute toxicity in rats and mice, as well as the diuretic activity in rats of the crude aqueous extract of dried leaves Palicourea coriacea (EABLPC). The acute oral toxicity EABLPC was investigated according to OECD 423. To evaluate the diuretic activity three groups of rats received doses of EABLPC (80, 160 and 320 mg / kg), one group received only saline solution, and another received furosemide (20 mg / kg) administered by gavage for eight days, being made volume measurement and evaluation of urinary concentrations of electrolytes (Na+, K+ and Cl-), creatinine and urea in urine and blood. The extract did not develop signs of toxicity or mortality in animals and found no pathological changes. In the evaluation of diuretic activity observed - an increase in urinary volume, water consumption and excretion of electrolytes, mice treated with EABLPC, compared to untreated, but not statistically significant differences were detected in blood samples. The results showed that the extract belongs to Class 5 (Substances with LD50 greater than 2000 mg / kg), being considered of low toxicity. The increase in urine volume, water consumption and excretion of electrolytes confirmed the diuretic activity of EABLPC. This study confirmed the use of ethnopharmacological EABLPC.Item AVALIAÇÃO DA TOXICIDADE ORAL AGUDA E DAS ATIVIDADES DIURÉTICA E ANTIOXIDANTE, DA Rudgea viburnoides (CHAM.) BENTH. (CONGONHA-DE-BUGRE)(Universidade Federal de Goiás, 2009-06-16) PUCCI, Liuba Laxor; CUNHA, Luiz Carlos da; http://lattes.cnpq.br/6349547031976679The Rudgea viburnoides (Cham.) Benth. (Rubiaceae), popularly known as "congonha, congonha-de-Bugre or Bugre" is used in folk medicine as diuretic, hypotensive, anti-rheumatic and depurative of blood (leaves tea). This species is being traded as "porangaba" and used in weight loss programs. This work aimed to study the acute toxicity, the diuretic and antioxidant activities of R. viburnoides. The test for acute toxicity in single dose was performed with the ethanolic crude extract, administered orally, at concentrations of 2000mg/kg and 5000mg/kg in mice and rats of both sexes by the testo of Class.To test for diuretic activity in rats, it was used the crude ethanolic extract of the leaves at concentrations of 40mg/kg, 80mg/kg and 160mg/kg, and furosemide 20mg/kg as positive control. The determination of total phenols of the crude extract and fractions (hexane, dichloromethane, ethyl acetate and methanol/water) was performed by the method of Butler and Hargerman and the evaluation of antioxidant activity performed by the method of 2,2-diphenyl-1- picryl -hidrazil (DPPH). There was no acute toxicity of crude ethanolic extract of the leaves and it was classified as non toxic.The results has shown that the ethanolic extract presented dependent dose diuretic effect higher than furosemide, used as positive control. The crude ethanolic extract showed 0.84% of total phenols, the fraction hexanic 0.44%, the dichloromethane fraction 1.91%, the fraction of ethyl acetate fraction 15.43% and the fraction methanol/water 7.92%. The ethyl acetate fraction showed better antioxidant action. The results obtained so far may justify the popular use of Rudgea viburnoides as diureticItem Validação do processo de esterilização por óxido de etileno para determinar o tempo de aeração em frascos enterais(Universidade Federal de Goiás, 2010-09-24) SANTOS, Hugo Campos Oliveira; CUNHA, Luiz Carlos da; http://lattes.cnpq.br/6349547031976679To enter the safety and sterility in enteral feeding bottles is necessary to validate the sterilization process. The aim of this study was to determine the aeration time residual enteral bottles sterilized by ethylene oxide. Enteral bottles 120 to achieve the qualification physical, microbiological and chemical in three consecutive cycles 534, 535 and 536. Physicals sensors and chemical integrators in the autoclave were installed to monitor the parameters of relative humidity (RH ≥ 35%), temperature (55ºC±10), pressure (0.750 kgf/cm²±50) and sterilization time (6h). Tests for sterility and endotoxin tests evaluated the result of rapid bioindicator for reading on 4h. We performed the validation of analytical method by gas chromatography (GCFID), as a technique to determine the concentration of ethylene oxide residue. The use of rapid bioindicator (Bacillus atrophaeus) was approved for sterility testing (14 days), test for endotoxin <0.5 EU/ml and elimination of microbial 12 logarithmic cycles (SAL10-6). The analysis technique (GCFID) was linearity in the range 1-50 μg/ml of EtO, 100.4% average accuracy, precision and robustness: RSD <5% (RE 899/2003, ANVISA). The residual dissipation was significant p<0.05 for all time aeration evaluated. After time 6h aeration was obtained 7.77±0.97 μg/ml of the EtO residual enteral bottles. This concentration was approved a limited of 10 μg/ml, acceptable for pharmaceutical products. The validation allowed approving the parameters of sterilization; the enteral bottles enter the sterile and determine the minimum time of 6h of aeration process.