FF - Faculdade de Farmácia
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Navegando FF - Faculdade de Farmácia por Por Orientador "Gil, Eric de Sousa"
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Item LQFM289: caracterização eletroquímica e computacional de um novo análogo da trimetozina para o tratamento da ansiedade(Universidade Federal de Goiás, 2024-12-21) Costa, André Gabriel Carmo; Macêdo, Isaac Yves Lopes de; http://lattes.cnpq.br/7801802836007488; Gil, Eric de Sousa; http://lattes.cnpq.br/3218622824233303; Gil, Eric de Souza; Santos, Pierre Alexandre dos; Rodrigues, Edson Sílvio Batista; Pereira, Eufrasia de SousaThis study employs electrochemical and Density Functional Theory (DFT) calculation approaches to investigate the potential of a novel analogue of trimetozine (TMZ) antioxidant profile. The correlation between oxidative stress and psychological disorders indicates that antioxidants may be an effective alternative treatment option. Butylatedhydroxytoluene (BHT) is a synthetic antioxidant widely used in industry. The BHT-TMZ compound derived from molecular hybridization, known as LQFM289 (Cabral et al., 2023), has shown promising results in early trials, and this study aims to elucidate its electrochemical properties to further support its potential as a therapeutic agent. The electrochemical behavior of LQFM289 was investigated using cyclic voltammetry (CV), square wave voltammetry (SWV), and differential pulse voltammetry (DPV), and a mechanism for the redox process was proposed based on the compound’s behavior. LQFM289 exhibits two distinct oxidation peaks: the first peak, (Ep1a ≈ 0.49V), corresponds to the oxidation of the phenolic fraction (BHT), and the second peak, (Ep2a ≈ 1.2 V vs. Ag/AgCl/KClsat), denotes the oxidation of the amino group from morpholine.Electroanalysis was used to identify the redox potentials of the compound, providing insight into its reactivity and stability in different environments. A redox mechanism was proposed based on the resulting peak potentials. The DFT calculation elucidates the electronic structure of LQFM289, resembling the precursors of molecular hybridization (BHT and TMZ), which may also dictate the pharmacophoric performance.Item Citometria de fase sólida aplicada ao teste de esterilidade do produto Cloreto de Sódio 0,9% Solução Injetável(Universidade Federal de Goiás, 2015-06-22) Silva, Gisele Badauy Lauria; Torres, Ieda Maria Sapateiro; http://lattes.cnpq.br/0836649494981715; Gil, Eric de Sousa; http://lattes.cnpq.br/3218622824233303; Torres, Ieda Maria Sapateiro; Garrote, Clévia Ferreira Duarte; Alves, Virginia Faria; Diniz, Danielle Guimarães AlmeidaThe sterility test is a test that certificate the absence of viable microorganisms in pharmaceutical raw materials, drugs and medical device. The Solid Phase Cytometry method (SFC) is based on the detection of viable cells through the use of viability markers reagents, that permeate the cell membrane and are cleaved by nonspecific esterase enzymes, forming the fluorochromes that are detected by ChemScan RDI® equipment. It is a fast and innovative method for the sterile injecting drugs area. The objective of the study was to evaluate and validate this technology applied to the sterility test, of the product Sodium Chloride (NaCl) 0.9% Injectable Solution, using the ChemScan RDI® equipment (CS RDI®). Eight microorganisms were evaluated, being six compendial (Clostridium sporogenes NCTC 12935 (ATCC 11437), Pseudomonas aeruginosa NCTC 12924 (ATCC 9027), Staphylococcus aureus NCTC 10788 (ATCC 6538), Bacillus subtilis NCTC 10400 (ATCC 6633), Aspergillus brasiliensis NCPF 2275 (ATCC 16404) and Candida albicans NCPF 3179 (ATCC 10231)) and two "in house” microorganisms, obtained from bioburden monitoring of pre sterilization (Micrococcus luteus and Staphylococcus epidermidis). The Solid Phase Cytometry methodology through logistic regression statistical analysis and Chi-square test, showed to be more rapid than the sterility test by membrane filtration (MF) for all tested microorganisms, reducing the analysis time from 14 days to about 3 hours. The method was validated by the use of qualitative parameters: specificity, limit of detection and robustness.