Mestrado em Ciências Farmacêuticas (FF)
URI Permanente para esta coleção
Navegar
Navegando Mestrado em Ciências Farmacêuticas (FF) por Por Orientador "Gil, Eric de Souza"
Agora exibindo 1 - 6 de 6
Resultados por página
Opções de Ordenação
Item Avaliação do processo eletroquímico na degradação de amoxicilina e determinação de toxicidade dos subprodutos gerados(Universidade Federal de Goiás, 2019-03-22) Caetano, Marcos Pereira; Gil, Eric de Souza; http://lattes.cnpq.br/3218622824233303; Gil, Eric de Souza; Garcia, Luane Ferreira; Comalti Júnior, FlávioIntroduction: Amoxicillin (AMX) is one of the world's most widely prescribed antibiotics for the treatment and prophylaxis of bacterial infections, in both human and veterinary medicine. The incomplete removal of this drug during the treatment of wastewater has attracted the attention of several researchers due to the risks of its bioaccumulation and consequent bacterial resistance. The electroemediation of drugs is of great value in the environmental scope, since electrochemical methods have several advantages when compared to the tools commonly used in the treatment of pharmaceutical and urban effluents. Objective: To evaluate the efficiency of the electrochemical process in the degradation of AMX using different electrolytic media and electrodes, as well as to investigate the adverse effects of the antibiotic before and after the electrochemical remediation. Methodology: The electrochemical tests were performed in three electrolytic media (tap water, Na2SO4 or NaCl solutions) and three anodes (carbon [C], titanium [Ti] and carbon modified with titanium oxide [TiO2 @ C]). The samples analyzed before and after the electro-oxidation were monitored by UV-visible, mass spectrometry and differential pulse voltammetry. After the electrooxidation process, the treated AMX solutions were analyzed by the ecotoxicity test with Danio rerio (zebrafish; paulistinha) and the minimum inhibitory concentration was calculated to determine the antimicrobial potential after treatment. Results and discussion: The titanium oxide modified carbon anode [TiO2 - C]) showed high efficiency, leading to the complete removal of amoxicillin in less than 10 minutes, in the order: [TiO2 @ C]> [Ti]> [C]. The dose of the electrolytes is supported in the following order: 0.1 M NaCl> Na 2 SO 4> 0.01 M NaCl> tap water. Amoxicillin does not pulse cardiac impressive of zebrafish during long term exposure. Conclusions: The electrooxidation of amoxicillin using TiO2 electrode in 0.01 M NaCl solution was able to decrease the antimicrobial activity of amoxicillin. At a high concentration of electrolyte, there is an increase in the rate of drug removal, there is why it is not the habitat that the zebrafish has become a toxic environment. The technique has been serous in the degradation of amoxicillin and can be applied to other organic pollutants.Item Sensores eletroanalíticos de sonogel e pasta de carbono para análise de paracetamol gotas(Universidade Federal de Goiás, 2015-03-30) Crispim, Denise Vaz Ferreira da Silva; Gil, Eric de Souza; http://lattes.cnpq.br/3218622824233303; Gil, Eric de Souza; Marreto, Ricardo Neves; Santos, Wallans Torres Pio dosParacetamol (N-acetyl-p-aminophenol or acetaminophen) is a drug with antipyretic, analgesic and anti-inflammatory, stands out as one of the most consumed worldwide. Because of this demand, the development and registration of new formulations by the pharmaceutical sector is ongoing. The process control and final product is an obligatory part of quality control. The official methods for quantitative determination of paracetamol include spectrophotometric and chromatographic techniques. In turn, due to the inherent electroactivity of this compound, the scientific literature involving electroanalytical methods is also large. Our objective was to demonstrate the efficiency of carbon electrodes modified with silica sonogel compared to conventional electrodes and official methods. The development and validation of an electroanalytical method for quantitative determination of paracetamol in liquid formulations. Apply the method in different product development phases, like product and reference, comparing the method developed with the official method of CLAE using conventional glassy carbon electrodes and carbon and sonogel folder. The samples consisted of a formulation drops reference (Tylenol®), 5 test formulations, standard solution of Paracetamol, all the 200 mg/mL. For differential pulse voltammetry (DPV) was used a potentiostat/galvanostat. Electrochemical cell with 5.0mL capacity, with three-electrode system, glassy carbon electrodes or sonogel, Pt ring and calomel (SCE), represented the electrodes working, auxiliary and reference, respectively. The VPD conditions were: 75mV pulse amplitude, pulse width of 0.4 is scanning speed of 5 mV/s. For chromatographic testing was performed using a UV detector at 272 nm, C18 column (200 mm x 4.6 mm x 10 microns) with a mobile phase flow 2 ml/min. The observed voltammetric profiles showed an anodic peak at 293 mV (vs. Ag/AgClsat, pH = 6.0), whose potential and current levels was lower than that observed for cabono of electrode. Have excipients showed no do not constitute interfering peaks. Carbon electrodes with nanostructured silica sonogel also showed good linearity and recovery rate (CV <5%) compared to standard solution and official method (CLAE). This fact combined with good selectivity, sensitivity, and low overall cost makes this very promising device for analysis of paracetamol formulations.Item Remediação bio-eletroquímica do hormônio sexual sintético 17-α-etinilestradiol(Universidade Federal de Goiás, 2016-03-28) Garcia, Luane Ferreira; Santiago, Mariângela Fontes; http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4784290Y6; Gil, Eric de Souza; http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4795650Y1; Gil, Eric de Souza; Santos, Wallans Torres Pio dos; Garcia, Telma Alves; Santiago, Mariângela Fontes SantiagoHormones are released constantly in sewage, originated by of human/animal excreta, or waste of pharmaceutical industries, not treated satisfactorily. The eviction of these pollutants in water resources produces great environmental impact, as disruption in animals’ endocrine system. The 17α-ethinylestradiol (EE2) is the most popular synthetic estrogen, which is found in water and in considerable concentrations. Several strategies are being studied to remedy this pollutant. Enzymes as laccases, which have low specificity, are able to oxidize various pollutants, thus suggesting their potential in the treatment of effluents. Another alternative are the electrochemical processes as electro-oxidation and electrocoagulation. The aim of this study was to evaluate the removal efficiency of the EE2 for biological or/and electrochemical process. The crude extract containing the laccase from Pycnoporus sanguineus was immobilized in Ca/Cu-alginate-chitosan beads. For partial characterization were determined optimum pH and optimum temperature of enzyme activity, for free and immobilized enzyme. Biological remediation was performed in these conditions: shaking (100 rpm); temperature at 28°C (± 2); times of 4, 8 and 24 hours; EE2 solution buffered at pH 4 and 5, and EE2 solution without addition of buffer. For the electrochemical remediation: magnetic stirring; voltage of 2.5, 5 and 7.5 V; times of 10, 20 and 40 minutes; pHs 5 and 7. For bio-electrochemical remediation the best conditions were used. In the remediation assays of the EE2 with immobilized enzyme, the best result was obtained for the support Ca-alginate-chitosan with 89.81% (± 2.71) removal, in sodium acetate buffer pH 5.0 and 24 hours of treatment. Under the same conditions to the free enzyme, 91.81% (± 0.86) of removal was obtained. For electrochemical remediation with titanium electrode, 86.21% (± 9.30) was removed in pH 7 phosphate buffer and 40 minutes. For sequential bio-electrochemical remediation, EE2 concentrations were below the limit of detection of the chromatograph, with the removal by immobilized enzyme acting in unbuffered solution. It can be concluded that the two technologies are very effective for the removal of the EE2.Item Caracterização eletroquímica do composto LQFM-091, obtido por hibridação molecular a partir dos protótipos nimesulida e BF-389(Universidade Federal de Goiás, 2015-12-17) Leite, Karla Carneiro de Siqueira; Gil, Eric de Souza; http://lattes.cnpq.br/3218622824233303; Gil, Eric de Souza; Menegatti, Ricardo; Comalti Júnior, FlávioNimesulide is an anti-inflammatory drug (NSAID) whose preferential selectivity for cyclooxygenase-2 (COX-2) leads to fewer adverse effects and wide use. Nimesulide, like other NSAIDs and selective COX-2 by inhibiting a single metabolic pathway of the arachidonic acid cascade are still responsible for gastrointestinal and cardiovascular side effects. However, recent studies show that the development of multi-targeted anti-inflammatory is an important strategy for obtaining the most effective drugs with fewer side effects. Therefore, the molecular changes from nimesulide has been proposed as a molecular hybridization with a derivative of butylhydroxytoluene BF-389. Such molecular modification products aim to inhibit metabolic pathways of two cascade of arachidonic acid, COX-2 and via the 5-lipoxygenase (LOX). Within the search string and development of new candidate drugs presenting prototypes of electroactive subunits, the characterization of the redox profiles can be made through the electrochemical techniques, which are characterized by speed, low cost and simplicity. In the electrochemical characterization of a new candidate prototype was observed two peaks with anode potential of 1.0V 0,42V and due to oxidation of aromatic amine and phenolic hydroxyl respectively. After analysis by varying the pH and scanning speed, it follows that mass transfer occurs via diffusion processes and proton transfer. The electrochemical analyzes, and are a supplementary means of characterization, were conclusive to prove that the electroactive groups are important in drug mechanism of action, remain free and yet, via a calibration curve constructed by measuring the current (i) due to the potential different concentrations of analyte, one can demonstrate the ability to dispense the new drug candidate developed.Item Métodos eletroanalíticos e ensaios de atividade antioxidante no controle de qualidade de mel(Universidade Federal de Goiás, 2015-03-30) Rezende, Stefani Garcia; Garcia, Telma Alves; http://lattes.cnpq.br/6340261924930737; Gil, Eric de Souza; http://lattes.cnpq.br/3218622824233303; Gil, Eric de Souza; Oliveira, Severino Carlos Bezerra; Santos, Wallans Torres Pio dosThe honey is a concentrated source of nutrients, it is used by animals and exploited as a natural resource for homes since antiquity. Many studies have tried to characterize the honey and its quality, but the complex natural process of production, involve that any research is not able to obtain fully satisfactory results. In this work 24 samples. Were studied 24 samples from honey producing regions located around Goiania - GO and some foreign samples (Portugual, USA and New Zelândias), those donated by the Beekeeping Association of the State of Goiás and these purchased in specialty stores in their respective countries . The physical and chemical tests as indicative of deterioration, hydroxymethylfurfural (HMF) and diastase activity (AD), followed parameters proposed by Normative Instruction N. 11/2000 of the Ministry of Agriculture, Livestock and Supply (MAPA). The antioxidant components analysis was used for traditional spectroscopic methods Folin-Ciocalteu (FC), Ferric Reducing Antioxidant Potential (FRAP), 2,2-diphenyl-1-picryl-hydrazyl (DPPH●); and electroanalytical calculated from the oxidation peaks voltammetric differential pulse (DPV) by Electrochemical Index (EI). While mid-infrared method (IR) and methods of multivariate statistical analysis were used for identification and classification of honey from different floral sources and/or regions. As for the deterioration analysis test (HMF and AD) 50% of the samples applied in these tests, for the control of physical and chemical quality, were at odds with the Normative Instruction N. 11/2000 of MAPA. All samples showed the presence of antioxidant compounds exposed by methods FC, FRAP, DPPH● and EI; and the method of FRAP was the one closest to the EI and the DPPH● was inversely proportional to EI, which may conclude that the electroanalytical by DPV is suitable for analysis of antioxidant compounds in honey. The infrared results coupled with chemometric tool, principal component analysis (PCA) and hierarchical cluster analysis (HCA), were not satisfactory for sample groups of the same floral origin and/or region, but suggested trend in results.Item Determinação eletroanalítica e espectrofotométrica da atividade antioxidante de fermentados de jabuticaba e vinhos de diferentes procedências(Universidade Federal de Goiás, 2013-03-28) Sá, Luísa Zaiden Carvalho Martins de; Torres, Ieda Maria S.; Gil, Eric de Souza; http://lattes.cnpq.br/3218622824233303; Gil, Eric de Souza; Silva, Elton Clementino da; Rocha, Matheus LavorentiThe consumption of wine has been associated with health promoting properties due to the high content of phenolic compounds, what makes wines an important dietary source of antioxidants. Jabuticaba fermented beverages, as much as wine, have a high content of phenolic compounds. In this study, traditional spectrophotometric methods (ABTS, DPPH, Folin-Ciocalteu) as well as novel methods (Cyclic Voltammetry - CV, Differential Pulse Voltammetry - DPV and Square Wave Voltammetry - SWV) have been used to evaluate the antioxidant activity of wines of different origin a jabuticaba fermented beverages and a jabuticaba brandy. Furthermore, an Electroanalytical Index (EI) has been proposed in order to allow the comparison of the antioxidant activity measured by electroanalytical methods. For the fermented beverages of jabuticaba, it has been demonstrated in the five methods that all three varieties, red, white and rose, have high antioxidant potential, very similar to a red dry wine, while the brandy has not shown any peaks in voltammetric analysis. In the analyzes by DPPH, red wines have shown about five times as much the antioxidant capacity of white wines, while for the EI it is twice as much when compared to white wines. Rose, white and fortified wines have shown lower EI than the red wine. It has been determined a Pearson correlation of -0.91097 between the DPPH method and the EI. The proposed EI allows comparison of the amount of electroactive compounds determined in the various wine samples analyzed. Considering the electroactive nature of the antioxidant compounds, electroanalytical methods have been demonstrated suitable for studying such compounds. Its main disadvantage was the high adsorption process due to the phenolic oxidation on the electrode´s surface, creating an isolating film on it. This process has been overcome by the use of carbon paste electrode.