Mestrado em Ciências da Saúde (FM)
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Navegando Mestrado em Ciências da Saúde (FM) por Por Área do CNPQ "CNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA"
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Item Atividade antimicrobiana e produção de enzimas de interesse biotecnológico de bactérias isoladas de diferentes habitats.(Universidade Federal de Goiás, 2009-03-17) RODRIGUES, Ariana Alves; VIEIRA, José Daniel Gonçalves; http://lattes.cnpq.br/1742731776579730The microorganisms are essential for the environment and contribute to stabilize the environments, playing a hole in the basic ecologic process such as biogeochemistry cycles and food chains, and sometimes responsible for the maintenance of the ecologic relationship between the organisms. So we have a diversity of microorganism and in consequence bioactive molecules that they produce as a result of primary and secondary metabolism, and are used by humans in many important social-economic activities, which includes the search for new medicines and new enzymes with biotechnology interest. This study analyzed different microorganisms isolated from different habitats, and the objective was select microorganisms with the capacity of inhibit the growing of pathogenic microorganisms and that produces enzymes with biotechnological applications. The isolates antimicrobial and enzymatic activities were evaluated, bioactive substances extracted and the cytotoxic activity with Artemia salina determined. The biggest part of the isolates produces substances with antimicrobial activity for the evaluated gram-positives, and none are toxic in low levels. The isolates are great producers of esterases and β-glucosidades. The isolates described in this study are from four different environments: Cerrado soil, Mata Atlântica, Azadirachta indica A. JUSS (Nim) e cave environment and are related to unique environmental conditions, the majority part of the isolates are able to produce molecules with biotechnology activity, this suggests a great microbial potential for the production of bioactive molecules that can be used in industries and medicine. Key Words: Antimicrobial activity, microorganisms, enzymes, bioactive.Item Micro-organismos envolvidos em infecções urinárias de mulheres com idade superior a 15 anos atendidas no HC-UFG em 2009 e os perfis de suscetibilidade aos antimicrobianos(Universidade Federal de Goiás, 2011-05-06) SANTOS SOBRINHO, Rosemary Alves dos; REIS, Cleomenes; http://lattes.cnpq.br/5103786277121402A urinary tract infection (UTI) is a very common disease and can occur at any age. The vast majority of UTIs is caused by enteric bacteria. The study aimed to identify the etiologic agents most frequently, the profile of antibiotic susceptibility and the factors possibly associated to the UTIs recurrents in women older than 15 years, cared for and / or admitted to the Hospital of the University of Goias. From March to November 2009, were invited and accepted to participate in the study 923 women in this age group and they were interviewed using a questionnaire about demographics data and risk factors for recurrent infections. Escherichia coli was the most frequent agent accounting for 67.9% of the total, followed by Enterobacter sp (6.2%), Klebsiella sp (6.2%), Proteus mirabilis (4.5%), Morganella morganii (4.0 %), Acinetobacter baumannii (2.8%) and Staphylococcus aureus (2.2%). %). E. coli showed higher rates of resistance to ampicillin in 46.7% patients with recurrent infection and 50.0% in infections nonrecurring; amoxicillin/clavulanate (32.6% and 35.7%), trimethoprim-sulfamethoxazole (30,0 and 25,0%, respectively) and 100,0% susceptibility to imipenem and nitrofurantoin in both groups. Enterobacter sp showed greater resistance to ampicillin, amoxicillin/clavulanic, norfloxacin and gentamicin (>88.0%) and greater susceptibility to amikacin, cefepime, imipinem and cephalosporins. Klebsiella sp showed high resistance to ampicillin and amoxicillin / clavulanate (> 60.0%) and greater susceptibility to quinolones (> 60.0%), amikacin and imipenem (100.0%) in both groups. There were no statistically significant differences between the risk for recurrent infection or not assessed for menopause, hypertension, hysterectomy, SEL (Systemic Erythematosus Lupus) and smoking. The only risk factor associated to recurrent infection in patients older than 50 years with diabetes. In this study, there was a greater number of E. coli in UTIs, followed by other enterobacteria such as Enterobacter sp and Klebsiella sp. Among all drugs tested, all the micro-organisms, were resistant generally to penicillins, being the most effective quinolones and carbapenems.