Mestrado em Ciências da Saúde (FM)

URI Permanente para esta coleçãohttp://200.137.215.59/tede/handle/tde/242

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Ciclofotocoagulação tradicional modificada versus slow coagulation no glaucoma refratário : um estudo prospectivo e randomizado
(Universidade Federal de Goiás, 2026-04-28) Pereira I, Eduardo Akio; Silva , Leopoldo Magacho dos Santos; https://lattes.cnpq.br/8749557033319190; Silva, Leopoldo Magacho dos Santos; Isaac, David Leonardo Cruvinel; Moraes Filho, Leiser Franco de
This prospective, randomized, and comparative study evaluated the hypothesis that complications of traditional cyclophotocoagulation (CPC) may be related not only to power and time parameters but also to the extent of the treated area. Although more recent protocols involving power reduction and increased exposure time (Slow Coagulation) have demonstrated an excellent efficacy/safety ratio, it was proposed to investigate whether a modification of the traditional technique with a smaller treatment extent could offer similar results. To this end, 48 eyes of 48 patients with refractory glaucoma were included and randomized into two groups of 24 patients each: Group I (GI) underwent a modification of the traditional technique using a power of 2500 mW for 2000 ms, limiting the treatment extent to 210° (180° inferiorly and 30° superiorly) with 21 spots, while Group II (GII) followed the standard Slow Coagulation protocol. After 12 months of follow-up, the intraocular pressure (IOP) reduction in GI was from 27.54 ± 12.65 mmHg to 14.80 ± 9.11 mmHg, and in GII from 33.92 ± 14.08 mmHg to 19.11 ± 11.60 mmHg (p < 0.001 for both). The number of topical medications was reduced from 3.17 ± 0.96 to 1.35 ± 1.42 in GI, and from 3.13 ± 0.95 to 0.94 ± 1.30 in GII (p < 0.001 for both). There was no statistically significant difference between the groups regarding the percentage of IOP reduction (p = 0.092), the reduction in the number of medications (p = 0.823), and visual acuity (p = 0.983), with the latter being preserved throughout the study in both GI (p = 0.868) and GII (p = 0.302). The success rate ranged from 21.0% to 61.1%, depending on the criterion: qualified 1 (GI 49.1%; GII 61.1%; p = 0.430), qualified 2 (GI 57.6%; GII 61.1%; p = 0.829), absolute (GI 21.0%; GII 31.0%; p = 0.207), and optimized (45.1% in both; p = 0.953); with no statistically significant differences between the groups. The predictive factors considered significant for surgical failure or success were: number of eye drops, use of oral acetazolamide, final energy, race, age, and sex. Conjunctival hyperemia was the most frequent complication, with a low number of severe complications in both groups and no statistical difference between them (p = 0.701). Thus, both evaluated cyclophotocoagulation techniques were safe, effective, and similar in the surgical treatment of patients with refractory glaucoma, suggesting that modifying the traditional technique with a smaller treatment extent is one of the pathways to achieve the best efficacy/safety ratio in CPC surgery.
Uso de cabine com ambiente controlado para medida de acuidade visual de Teller em comparação com o método tradicional em crianças de 12 a 36 meses
(Universidade Federal de Goiás, 2024-11-26) Queiroz, Gustavo Henrique Medeiros; Isaac, David Leonardo Cruvinel; http://lattes.cnpq.br/5474072354473614; Isaac, David Leonardo Cruvinel; http://lattes.cnpq.br/5474072354473614; Taleb, Alexandre Chater; http://lattes.cnpq.br/3191620401627150; Santana, Tainara Sardeiro de; http://lattes.cnpq.br/2154032892079554
Embargada.
Ocorrência de alergia a proteína do leite de vaca não IgE mediada em lactentes que receberam probióticos (Lactoba cillus acidophilusNCFM) e placebo.
(Universidade Federal de Goiás, 2025-12-15) Oliveira , Patrícia dos Santos; Costa, Paulo Sérgio Sucasas da; http://lattes.cnpq.br/9224543529268366; Costa, Paulo Sérgio Sucasas da; Vilela, Maria Ivone Pinto; Marques, Solomar Martins
Introduction: The prevalence of allergic diseases has increased significantly in recent years, with food allergies, particularly cow's milk protein allergy (CMPA), standing out in this scenario. The existence of an "atopic march" is known, referring to a sequence of allergic diseases that develop throughout life and are believed to share some pathophysiological mechanisms. The most recent studies link the genesis of these diseases to an imbalance in the gut microbiome, resulting in a "microflora of allergic disease". Objective: To evaluate the effect of supplementation with the probiotic Lactobacillus acidophilus NCFM on the occurrence of non-IgE-mediated cow's milk protein allergy in infants. Methods: This is a retrospective cohort study that evaluated infants who participated in a previous study entitled "Effect of the use of probiotics (Lactobacillus acidophilus) on colic in infants: a double-blind, controlled, PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS DA SAÚDE randomized clinical trial". The study population was selected from infants who participated in the initial project, with a final sample size of 37 infants. A questionnaire was administered to the parents of the 37 children included in the study. Data were collected using specific questionnaires and analyzed using IBM® SPSS Statistics version 20 software (Armonk, New York). Results: The relative risk of developing non-IgE-mediated cow's milk protein allergy (CMPA) was 0.33 in the group that received the probiotic (95% CI 0.04 - 2.66), without statistical significance. Conclusion: A tendency to develop non-IgE-mediated CMPA was observed in infants who received a placebo. Lactobacillus acidophilus may modulate the allergic immune response by enhancing intestinal barrier function, increasing the production of short-chain fatty acids, reducing the production of inflammatory cytokines, and promoting a more tolerogenic microbiome.
Estudo comparativo entre agulhas de 25x0,70mm ou 20x0,55mm para anestesia retrobulbar com baixo volume anestésico em tratamento de catarata por facoemulsificação
(Universidade Federal de Goiás, 2008-12-12) Carneiro, Haroldo Maciel; Silva, Leopoldo Magacho dos Santos; http://lattes.cnpq.br/2681402673708482; Silva, Leopoldo Magacho dos Santos; Ávila, Marcos Pereira de; Isaac, David Leonardo Cruvinel
To compare quality and safety of retrobulbar anesthesia (RBA) for phacoemulsification using needles of two different sizes: 25x0.7mm or 20x 0.55mm. Methods: This is a prospective, comparative study with patients undergoing cataract surgery with phacoemulsification. After support measures and sedation, all patients were submitted to retrobulbar anesthesia with a single inferior-lateral punction with 4ml of ropivacaína 1% with hyaluronidase- 50 U/ml. The patients were randomized to group I (GI), with a 25x0.7mm needle, or group II (GII), with a 20x0.55mm needle. In one pacient in each group, a computorized tomography was done during the ARB, and five minutes atfter the anesthetic solution injection. The quality of the procedure was obtained measuring ocular motility at three, five and ten minutes after the RBA. The incidence of adverse events was observed. The surgeon’s and patient’s satisfaction was measured with a standard questionnaire. Results – Fifty-four patients were included (27 in each group). No patient in either group complained pain, proprioception or light perception during the surgery. The surgeons considered the quality of the anesthesia very good or excellent in 96%, and the patients in 100% in both groups. There was no statistically difference comparing the need of multiple punctures between the groups. There was less ocular motility in GI at 3 minutes (0.6±1.1 vs 1.3±1.4, p=0.03). There was no statistically difference in ocular motility at 5 minutes. The needle tip was displaced in the intraconal space in both groups. No adverse event was related in the study. Conclusion- The RBA with 20x5.5mm with low volume of anesthetic is a safe and effective option for anesthesia in phacoemulsification surgery
Caracterização psicopatológica, neuropsiquiátrica e de neuroimagem das hipomanias funcionais e orgânicas (Mória)
(Universidade Federal de Goiás, 2025-01-31) Rabahi, Arthur; Caixeta, Leonardo Ferreira; http://lattes.cnpq.br/9536747113677509; Caixeta, Leonardo Ferreira; http://lattes.cnpq.br/9536747113677509; Souza, Weimar Kunz Sebba Barroso de; http://lattes.cnpq.br/6847019017274804; Daker, Mauricio Viotti; http://lattes.cnpq.br/9095500612457571
Embargada
Perfil dos pacientes submetidos a aplicação de injeção intravítrea de anti-VEGF no Centro de Referência em Oftalmologia do Hospital das Clínicas da Universidade Federal de Goiás entre novembro de 2017 e janeiro de 2021
(Universidade Federal de Goiás, 2025-09-24) Ximenes, Rodrigo Álvares Salum; Isaac, David Leonardo Cruvinel; http://lattes.cnpq.br/5474072354473614; Isaac, David Leonardo Cruvinel; Ávila, Marcos Pereira de; Mendonça, Luísa Salles de Moura
Embargado
Mini-implante versus implante convencional para overdenture maxilar: Avaliação das taxas de indicação a partir do planejamento cirúrgico digital
(Universidade Federal de Goiás, 2025-11-21) Adorno, Marcelo Rocha; Leles, Cláudio Rodrigues; http://lattes.cnpq.br/6740286066154410; Leles, Cláudio Rodrigues; http://lattes.cnpq.br/6740286066154410; Costa, Nádia do Lago; http://lattes.cnpq.br/9120865567187887; Silva, Fernanda Paula Yamamoto; http://lattes.cnpq.br/0511229119340734
Resumo
Perfil epidemiológico de retinopatia da prematuridade Em pré-termos assistidos em um hospital terciário do centro-oeste: Estudo trasnversal
(Universidade Federal de Goiás, 2025-11-18) Queiroz, Victória Coelho Jácome; Gomes, Maria Bárbara Franco; http://lattes.cnpq.br/7394332970179505; Costa, Paulo Sérgio Sucasas da; http://lattes.cnpq.br/9224543529268366; Costa, Paulo Sérgio Sucasas da; http://lattes.cnpq.br/9224543529268366; Vilela , Maria Ivone Oliveira Pinto; Fortes, Patrícia Marques; http://lattes.cnpq.br/9816674348461951
Resumo
Doença de Chagas: A Importância do Histórico Familiar em Indivíduos Atendidos em Hospital Universitário no Estado de Goiás
(Universidade Federal de Goiás, 2025-11-27) Rodrigues, Ernilva dos Santos; Ostermayer, Alejandro Luquetti; http://lattes.cnpq.br/1233757220404080; Oliveira, Enio Chaves de; http://lattes.cnpq.br/7046861881778720; Oliveira, Enio Chaves de; http://lattes.cnpq.br/7046861881778720; Castro, Ana Maria de; http://lattes.cnpq.br/9232309971000621; Bafutto, Alexandre Augusto Ferreira
Resumo
Avaliação colônica por enema baritado de pacientes chagásicos com e sem constipação
(Universidade Federal de Goiás, 2025-10-03) Bittar Neto, Jarbas Jabur; Oliveira, Ênio Chaves de; http://lattes.cnpq.br/7046861881778720; Oliveira, Ênio Chaves de; http://lattes.cnpq.br/7046861881778720; Bafutto, Mauro; http://lattes.cnpq.br/6075384881986001; Rezende Filho, Joffre; http://lattes.cnpq.br/4676204316384198
Embargada.
Comparação de dois aparelhos de biometria óptica no cálculo da lente intraocular em pacientes com ceratocone
(Universidade Federal de Goiás, 2024-08-29) Salgado, Larissa Fernanda Queiroz Elias; Fernandes, Marcos Rassi; http://lattes.cnpq.br/3918453247388300; Fernandes, Marcos Rassi; http://lattes.cnpq.br/3918453247388300; Mendonça, Luísa Salles de Moura; http://lattes.cnpq.br/2346628944052737; Stival, Larissa Rossana Souza; http://lattes.cnpq.br/6178756054679892
The purposes of this study were to compare and correlate the biometric parameters obtained by the devices, IOLMaster 700 and Lenstar LS 900, in patients with keratoconus; and to verify which parameter interferes most in the calculation of the power of the intraocular lens (IOL) in these patients. Sixty eyes of patients aged 18 years or older with keratoconus were prospectively evaluated using corneal tomographic criteria, who had not undergone any previous corneal surgical procedure and without any corneal opacity, originating from the Ophthalmology Reference Center (CEROF) of the Federal University of Goiás (UFG) from April 2023 to August 2023. The following biometric data were compared between the devices: axial diameter (AL), flattest keratometry (K1), most curved keratometry (K2), corneal astigmatism (ASTIG), anterior chamber depth (ACD) and calculation of the intraocular lens (IOL) power. The comparison of means and agreement analysis between the devices was tested using the paired t-test and Pearson's correlation analysis, respectively. The correlation between IOL Master and Lenstar was positive, with r > 0.85 in all parameters evaluated. There was a statistically significant difference in the evaluation of the means between the biometric parameters evaluated (K1, K2, ASTIG, ACD and LIO) in the t-test with p<0.001, with no statistically significant difference in relation to the AL parameter. In the multiple linear regression analysis, K2 was the main factor responsible for the variation in LIO values between the biometers with t of 2.93 and p<0.001. It is concluded that there is a discrepancy between the parameters evaluated through the biometers in patients with keratoconus, with a consequent difference in the LIO power, which may result in future postoperative refractive error. Therefore, the IOL Master 700 and Lenstar LS900 devices are not coincident in these patients
Análise da interface em diferentes sistemas de pinos de fibra de vidro e em técnicas de cimentação por meio de um novo software de tomografia computadorizada de feixe cônico
(Universidade Federal de Goiás, 2022-06-28) Cruvinel Filho, Jorge Luiz de Oliveira; Rocha, Sicknan Soares da; http://lattes.cnpq.br/8256226109956656; Estrela, Carlos; http://lattes.cnpq.br/4939545848747102; Estrela, Carlos; Alencar, Ana Helena Gonçalves de; Paula, Juliê Marra de
Embargado
Avaliação da esofagopatia chagásica por manometria de alta resolução de perfusão
(Universidade Federal de Goiás, 2025-08-29) Silva, Talita Ramos De Alencar; Oliveira, Enio Chaves de; http://lattes.cnpq.br/7046861881778720; Rezende Filho, Joffre; http://lattes.cnpq.br/4676204316384198; Oliveira , Enio Chaves de; http://lattes.cnpq.br/7046861881778720; Bafutto , Mauro; http://lattes.cnpq.br/6075384881986001; Souza, Diogo Henrique Saliba de
Resumo
Avaliação das atividades toxicogenéticas e angiogênicas da lectina purificada de Canavalia maritima (ConM)
(Universidade Federal de Goiás, 2025-08-22) Paiva, Felipe Eduardo Alves de; Teixeira, Claudener Souza; http://lattes.cnpq.br/0728801046272432; Cardoso, Clever Gomes; http://lattes.cnpq.br/9545455455623006; Cardoso, Clever Gomes; http://lattes.cnpq.br/9545455455623006; Franchi, Leonardo Pereira; http://lattes.cnpq.br/8068976548504815; Chen, Lee Chen; http://lattes.cnpq.br/4621907105842007
Embargada.
Transtornos dissociativo e conversivo: aspectos psicopatológicos, comorbidades e fatores fisiopatogênicos
(Universidade Federal de Goiás, 2024-06-11) Bannach, Mariana Lima Caetano; Caixeta, Leonardo Ferreira; http://lattes.cnpq.br/9536747113677509; Caixeta, Leonardo Ferreira; http://lattes.cnpq.br/9536747113677509; Almeida, Alexander Moreira; http://lattes.cnpq.br/9072644751174322; Vêncio, Sérgio Alberto Cunha; http://lattes.cnpq.br/8930226981827995
Embargada.
Avaliação do programa de formação no cuidado às pessoas com doenças crônicas não transmissíveis na atenção primária à saúde do estado de Goiás
(Universidade Federal de Goiás, 2024-12-17) Dias, Iohanna Maria Guimarães; Santos, Patricia Tavares dos; http://lattes.cnpq.br/8052298165888796; Rocha, Bárbara Souza; http://lattes.cnpq.br/8046110202782418; Rocha, Bárbara Souza; Pereira, Edna Regina Silva; Nunes, Cynthia Assis de Barros
Resumo
Avaliação da funcionalidade e incapacidade do indivíduo pós bloqueio anestésico na capsulite adesiva secundária
(Universidade Federal de Goiás, 2021-09-16) Nunes, Sara Ribeiro; Fernandes, Marcos Rassi; http://lattes.cnpq.br/3918453247388300; Fernandes, Marcos Rassi; http://lattes.cnpq.br/3918453247388300; Ribeiro, Luciana Castaneda; http://lattes.cnpq.br/4803387502034526; Assis, Thaís Rocha; http://lattes.cnpq.br/2272528203008924
Embargada.
Associação de variantes genéticas em LXRA e LXRB com fenótipos de Esclerose Lateral Amiotrófica
(Universidade Federal de Goiás, 2025-07-08) Bittar, Jacqueline Soares Barros; Reis, Angela Adamski da Silva; Santos, Rodrigo da Silva; http://lattes.cnpq.br/4806187026900959; Santos, Rodrigo da Silva; Barbosa, Mônica Santiago; Franchi, Leonardo Pereira
Amyotrophic Lateral Sclerosis (ALS) is a chronic, fatal neurodegenerative disease that affects motor neurons and leads to premature death. In most cases, its etiology remains unknown. The LXRA and LXRB genes encode the LXR-alpha and LXR-beta proteins, respectively. These nuclear receptors function as key transcription factors involved in lipid metabolism and exert neuroprotective and anti-inflammatory effects in the central nervous system. Objective: This study investigated the association between the genetic variants rs2279238 (LXRA) and rs2695121 (LXRB) and ALS phenotypes. Materials and methods: This is a casecontrol study conducted with 115 patients diagnosed with amyotrophic lateral sclerosis (ALS) and 115 control participants without neurodegenerative diseases, matched by sex and age, from the Central-West region of Brazil, between 2017 and 2024. Single nucleotide variants (SNVs) were identified using real-time polymerase chain reaction (qPCR). Results: The LXRA variant rs2279238 showed similar genotypic frequencies in both the case and control groups, indicating no significant association with ALS risk. However, the LXRB variant rs2695121 showed a strong association with ALS phenotypes. In the codominant inheritance model, individuals with the C/T genotype had a 2.5-fold increased risk (p = 0.002), and those with the T/T genotype had a 3.7- fold increased risk (p = 0.005), compared to the C/C wild type. The dominant model (C/T + T/T vs. C/C) indicated a 2.7-fold higher risk (p < 0.001). In the overdominant model (C/T vs. C/C + T/T), heterozygotes had an odds ratio of 1.81 fold increased risk (p = 0.025), suggesting an independent association with disease risk. When analyzing gene-gene interactions, individuals with the heterozygous rs2279238 (LXRA) variant combined with the wild-type rs2695121 (LXRB) genotype exhibited a reduced risk of ALS, with a statistically significant association (OR = 0.31; p = 0.049). Discussion: These findings suggest an association between the LXRB gene and ALS susceptibility and highlight the potential modulatory role of LXRA in reducing risk when in heterozygous form. Further research is warranted to clarify the underlying mechanisms and to explore the role of LXR proteins in ALS pathophysiology. Conclusion: The rs2695121 variant in the LXRB gene is associated with ALS phenotypes. While the rs2279238 variant in LXRA was not directly associated with the disease, its presence in heterozygous form may confer a protective effect when combined with the wild-type LXRB genotype.
Tendência temporal das Práticas Integrativas e Complementares no estado de Goiás e suas macrorregiões de saúde: avaliação do período de 2014 a 2022
(Universidade Federal de Goiás, 2025-04-29) Mariosa, Natália De Filippo; Barbosa, Maria Alves; http://lattes.cnpq.br/5025797873585225; Barbosa, Maria Alves; http://lattes.cnpq.br/5025797873585225; Oliveira, Michele Dias da Silva; http://lattes.cnpq.br/2294835800087293; Zapata, Marco Tulio Antonio Garcia; http://lattes.cnpq.br/3672512339058369
Embargado
Análise da síndrome de burnout em mulheres mães trabalhadoras da área da saúde
(Universidade Federal de Goiás, 2025-07-19) Damaceno, Nara Siqueira; Marciano, Rafaela Paula; http://lattes.cnpq.br/2719045150171823; Amaral, Waldemar Naves do; http://lattes.cnpq.br/4092560599116579; Amaral, Waldemar Naves do; Porto, Maria Laura de Almeida; Montalvão, Luciano Alvarenga
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