Mestrado em Ciências da Saúde (FM)
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Item Detecção das desordens potencialmente malignas de lábio e cavidade oral (DBPM): modelo de informação para a atenção primária em saúde(Universidade Federal de Goiás, 2024-07-19) Castilho, Suse Barbosa; Zara, Ana Laura de Sene Amâncio; http://lattes.cnpq.br/3893158152564208; Ribeiro-Rotta, Rejane Faria; http://lattes.cnpq.br/9466795079344876; Ribeiro-Rotta, Rejane Faria; Meurer , Maria Inês; Zinader, Juliana Pereira de Souza; Lucena, Fábio Nogueira de; Amaral, Rita GoretiFor the effectiveness of early detection of oral cancer (OC), greater investments in public policies to strengthen Primary Health Care (PHC) actions are necessary, including the use of information and communication technologies to support clinical decision-making. Information models (IM) can guide clinical assessment in health as well as the development of interoperable electronic health information systems, particularly in PHC, where they can contribute to more accurate referrals to other levels of health care. Objective: To propose an IM for the detection of potentially malignant oral disorders (PMOD) in PHC. Method: This is a qualitative study with a descriptive approach, using action research, associated with the Delphi Method. The study was organized into three stages: 1) identification of the minimum set of clinical criteria (MSCC) to support the differential diagnosis of PMOD; 2) validation of the MSCC and establishment of a Delphi Panel; 3) structuring of the IM. Results: A preliminary version of the CMCC was prepared by a specialist, submitted to pre-testing in the format of an electronic questionnaire on the REDCapⓇ Platform, generating a final version that was submitted to validation by the Delphi method, by 21 panelists (specialist dentists with experience in the diagnosis of PMDD). A total of 90% (n = 19/21) of the panelists responded to the first round and 86% (n = 18/21) responded to the second. All changes suggested in each round were analyzed, considering the Content Validity Index (CVI) ≥ 0.83. The Delphi Panel was completed in two rounds. The validated version of the CMCC resulted in a set of 30 questions, distributed in seven sections. From this CMCC, an MI was proposed in the format of a table, containing 80 data elements in the rows, structured in seven sections: anamnesis/sociodemographic information (n=9); anamnesis/history and lifestyle habits (n=16); clinical presentation of the lesion (n=18); clinical diagnosis (n=2); histopathological diagnosis (n=2); clinical conduct (n=1) and differential diagnosis (n=34). In the columns, the elements are arranged according to level, occurrence, description, type of data and standard codes. Conclusions: The MSCC developed and validated for the differential clinical diagnosis of PMOD represents an important step in obtaining the fundamental data elements for the definition of the IM and for the construction of an interoperable Computational Model for PHC. This could contribute to advances in the digital transformation of health within the context of oral health, with a potential impact on the quality of health care.Item Avaliação das alterações da microvasculatura fovel na angiografia por tomografia de coerência óptica em olhos de pacientes com diabete tipo 2, diagnosticados há mais de 5 ano, sem sinais clínicos de retinopatia diabética, versus paciente sem diabetes(Universidade Federal de Goiás, 2024-04-02) Pires, Alexandre Caiado Ferreira; Isaac, David Leonardo Cruvinel; http://lattes.cnpq.br/5474072354473614; David Leonardo Cruvinel; Isaac, David Leonardo Cruvinel; Silva, Leopoldo Magacho dos Santos; Taleb, Alexandre ChaterEmbargada.Item Anfotericina B no manejo terapêutico das infecções fúngicas invasivas: revisão sistemática da literatura com metanálise(Universidade Federal de Goiás, 2023-09-28) Abrão, Mirela Pereira Lima; Soares, Renata de Bastos Ascenço; http://lattes.cnpq.br/2129359947528992; Garcia Zapata, Marco Tulio Antonio; http://lattes.cnpq.br/3672512339058369; Garcia Zapata, Marco Tulio Antonio; Barbosa, Maria Alves; Santos, Sônia de Fátima OliveiraEmbargadoItem Monitoramento de tempo e conscientização no uso de smartphones: análise e comparação do efeito de intervenções na redução do tempo de uso(Universidade Federal de Goiás, 2025-03-01) Noronha Júnior, Sérgio Andrade; Amaral, Waldemar Naves do; http://lattes.cnpq.br/4092560599116579; Amaral, Waldemar Naves do; Alves, Rosane Ribeiro Figueiredo; Sousa, Juarez Antonio deEmbargado.Item Avaliação das Funções Cognitivas dos pacientes com Lúpus Eritematoso Sistêmico(Universidade Federal de Goiás, 2022-10-06) Vieira, Juliana Rosa Pires; Fernandes, Marcos Rassi; http://lattes.cnpq.br/391845324738830; Fernandes, Marcos Rassi; Paiva, Yara Bezerra de; Dias, Danilo RochaIntroduction: Neurocognitive changes may hinder the autonomy and independence of patients diagnosed with Systemic Lupus Erythematosus (SLE), being considered as one of the main negative outcomes. Objectives: To evaluate the cognitive functions of patients diagnosed with active SLE and in remission, at the Rheumatology Outpatient Clinic of the Hospital das Clínicas, School of Medicine, Universidade Federal de Goiás. Methodology: This was a cross-sectional study, non-probabilistic sample and consecutive type. Mini Mental State Examination (MMSE), Five Digits Test (FDT) and Rey's Complex Figures (FCRey) were used in 83 patients, in the period from November 2021 to May 2022. Patients with depressive disorders and users of alcohol and other drugs were excluded. Results: In the assessed cognitive functions - attention, memory, language and executive functions - showed mild impairments, corroborating with previous studies. When comparing groups of patients with active SLE and in remission there was no significant difference (p>0.005) in relation to cognitive performance. Conclusion: In this sense, cognitive dysfunctions were present both in patients with active SLE and in remission, the results showed mild cognitive impairment in patients diagnosed with SLE.Item Análise Clínica, Histopatológica E Do Perfil Inflamatório De Pacientes Portadores De Rinossinusite Crônica Com Polipose Nasal Em Um Hospital Universitário Terciário Do Centro-Oeste Do Brasil(Universidade Federal de Goiás, 2024-01-25) Rodrigues, Stela Oliveira; Avelino, Melissa Ameloti Gomes; http://lattes.cnpq.br/0519039948275501; Avelino, Melissa Ameloti Gomes; Lima, Wilma Terezinha Anselmo; Nakanishi, MárcioIntroduction: Chronic rhinosinusitis (CRS) is a disease with several clinical manifestations and endotypic characterization is widely studied for better therapeutic planning. The understanding of the profile of service patients is essential for better management. We aimed to elucidate the clinical and histopathological profile of patients with CRS with nasal polyps (CRSwNP) followed up at a tertiary hospital in the Brazilian Midwest, classifying them according to the predominance of inflammatory response. Methods: Patients with CRSwNP at the Hospital das Clínicas of the Federal University of Goiás were analyzed, trough the application of tomographic and endoscopic scores, clinical control of the disease, in addition to performing prick-test, biopsy of polyps (for histopathological analysis) and collection of epidemiological data. Furthermore, data from literature about the characteristics of the eosinophilic inflammatory response (type 2 pattern) were collected. Results: In descriptive analysis, a predominance of eosinophilic infiltration was observed in middle-aged patientes, with a majority of males, with comorbidities of asthma, allergic rhinitis and atopic dermatitis. There were no significant correlations between eosinophilia and the other data analyzed for each patient. In our systematic review, the main cytokines involved in the type 2 responde were highlighted. Conclusion: In the epidemiological evaluation of patients with CRS at the Hospital das Clínicas, we found a higher prevalence of eosinophilic infiltration, without significant correlations with other epidemiological data, similar to those found in the literature. The cytokines most involved in the type 2 response pattern in nasal polyposis are interleukin (IL)-4, IL-5 and IL-13.Item Osteossarcopenia em idosos: prevalências, fatores associados e efetividade de intervenções com exercício físico(Universidade Federal de Goiás, 2021-10-04) Souza, Guilherme Vinícius Elias; Noll, Matias; http://lattes.cnpq.br/3709020347400351; Silveira, Erika Aparecida da; http://lattes.cnpq.br/3801865783333828; Silveira, Erika Aparecida da; Vieira, Carlos Alexandre; Gadelha, André BonadiasEmbargadoItem Programa Nacional para Otimizar a detecção de Fibrilação Atrial paroxística RITMO PROTOCOL(Universidade Federal de Goiás, 2024-11-07) Andrade, Rodrigo Paashaus de; Souza, Weimar Kunz Sebba Barroso de; Souza, Ana Luiza Lima; http://lattes.cnpq.br/6578713509935374; Souza, Ana luiza Lima; Miranda, Roberto Dischinger; Vitorino, Priscila Valverde de OliveiraEmbargado.Item Sistema renina-angiotensina-aldosterona: Existe associação genética entre o polimorfismo I/D da enzima ECA com a esclerose lateral amiotrófica?(Universidade Federal de Goiás, 2024-12-05) Bento, Dhiogo da Cruz Pereira; Reis, Angela Adamski da Silva; Santos, Rodrigo da Silva; http://lattes.cnpq.br/4806187026900959; Santos, Rodrigo da Silva; Silveira, Luciana Carvalho; Jesuíno, Rosália Santos Amorim; ReisEmbargado.Item Influência dos níveis de hemoglobina sobre o risco e indicadores de sarcopenia em pacientes com câncer do aparelho digestivo(Universidade Federal de Goiás, 2024-12-09) Correia, Elisa Silva; Pimentel, Gustavo Duarte; http://lattes.cnpq.br/2291502930022342; Pimentel, Gustavo Duarte; Katashima, Carlos Kiyoshi; Martins, Karine AnuscaEmbargado.Item Análise das interconsultas psiquiátricas em hospital universitário de referência do centro-oeste brasileiro(Universidade Federal de Goiás, 2025-03-07) Silva, Sávio Augusto Teixeira e; Soares, Leonardo Ribeiro; http://lattes.cnpq.br/1610585108528260; Soares, Leonardo Ribeiro; Costa, Paulo Sérgio Sucasas da; Roza, Thiago HenriqueEmbargada.Item Acessibilidade, barreiras e soluções no atendimento em saúde das pessoas surdas que usam a Libras durante a pandemia do COVID-19(Universidade Federal de Goiás, 2025-02-26) Toledo, Luiz Alexandre Pereira de; Martín, Dolores Rodríguez; Duarte, Soraya Bianca Reis; Chaveiro, Neuma; http://lattes.cnpq.br/1345257253831999; Chaveiro, Neuma; Lima, Hildomar José de; Zapata, Marco Tulio Antônio GarciaConteúdo embargadoItem Performance diagnóstica da ultrassonografia transfontanela na detecção de lesões do sistema nervoso central em neonatos: um estudo comparativo com ressonância magnética(Universidade Federal de Goiás, 2025-02-10) Teles Filho, Ricardo Vieira; Costa, Paulo Sérgio Sucasas da; http://lattes.cnpq.br/9224543529268366; Costa, Paulo Sérgio Sucasas da; Diniz, Denise Sisterolli; Fortes, Patrícia MarquesConteúdo embargadoItem Contribuições da prática de yoga na percepção dos sintomas de estresse, ansiedade e depressão em estudantes universitários(Universidade Federal de Goiás, 2025-03-11) Lemes, Uitairany do Prado; Borges, Cezimar Correia; http://lattes.cnpq.br/3658236531711777; Chaveiro, Neuma; http://lattes.cnpq.br/1345257253831999; Chaveiro, Neuma; Guimarães, Valeriana de Castro; Paiva, Rosane EmanueleIntroduction: University students are particularly susceptible to increased stress, anxiety, and depression, especially medical students. Yoga, a non-pharmacological alternative, has gained legitimacy due to its inclusion in Integrative and Complementary Practices, ease of application in Higher Education Institutions, and evidence on mental health parameters. This dissertation investigated the effects of yoga on the mental health of university students through a systematic review protocol, a systematic review, an integrative review, and an experimental study. The central objective was to determine if a yoga program could reduce stress, anxiety, and depression, and improve self-reported quality of life. The research was structured into four articles, each addressing a specific aspect of yoga's effects in the academic context. Products: The systematic review analyzed 12 experimental studies with 1,660 participants. Yoga showed significant effects, most notably in reducing stress, followed by anxiety, and to a lesser extent, depression. Hatha Yoga was the most studied modality, with interventions lasting 6 to 12 weeks. Methodological quality was assessed using Cochrane tools: five studies had low risk of bias, six had moderate risk due to randomization and blinding issues, and one had high risk. The integrative review focused on stress, synthesizing 10 articles that showed yoga effectively reduces perceived stress, with moderate to small effects. Combining physical practices, breathing exercises, and meditation was particularly effective. Hatha Yoga was the most frequent modality. The review highlighted the need for more research on the optimal intensity and proportion of movements and meditation. The experimental study involved 48 medical students in two groups: Yoga Group (GY) and Meditation Counseling Group (GAM). Over 8 weeks, pre- and post-intervention assessments measured stress, anxiety, depression, and quality of life. In GY, anxiety scores (GAD-7) dropped from 13.4 ± 4.7 to 5.8 ± 4.4 (p < 0.001), indicating a large effect; in GAM, from 13.2 ± 5.0 to 8.8 ± 5.1 (p = 0.010). For stress (EPS10), GY scores fell from 27.5 ± 4.6 to 19.4 ± 2.4 (p < 0.001), a large effect; GAM scores decreased from 26.4 ± 6.4 to 20.2 ± 6.8 (p < 0.001). Depression (DASS-21) showed small to moderate effects in GY and moderate to large in GAM. Quality of life (SF-12) improved slightly in GY (p = 0.075 for physical health; p = 0.270 for mental health), without statistical significance. Conclusions: Yoga is an effective intervention for reducing stress, anxiety, and, to a lesser extent, depression among university students, especially in medical school. Implementing regular yoga programs in universities can promote a healthier academic environment. Future research should explore longer interventions and various yoga modalities to enhance these benefits furtherItem Desenvolvimento e validação de metodologia bioanalítica e sua aplicação para a determinação da farmacocinética e biodistribuição do paclitaxel e genisteína co-encapsulados em nanopartículas multicompartimentais(Universidade Federal de Goiás, 2014-05-29) Veloso, Danillo Fabrini Maciel Costa; Lima, Eliana Martins; Lima, Eliana Martins; Santos, Pierre Alexandre dos; Antoniosi Filho, Nelson RobertoUltra-sensitive and specific bioanalytical methods are needed to quantify drugs used in cancer treatment and monitor its absorption, distribution and elimination in body fluids and tissues. Most anticancer drugs are relatively unstable substances, subject to an intensive metabolism in vivo and degradation during pretreatment of the sample. Thus, due to high specificity, sensitivity and not mandatory derivatization, high efficiency liquid chromatography coupled to mass spectrometry has emerged as one of the techniques for in vivo monitoring of drugs for appropriate cancer treatment. This study investigated the pharmacokinetics and biodistribution of paclitaxel and genistein after intraperitoneal administration in mice, in a formulation where paclitaxel was encapsulated in polymeric nanoparticles, coated with a lipid bilayer containing genistein. A bioanalytical method was developed and validated according to the Food and Drugs Administration and RDC 027/2012 ANVISA. To prepare the samples was used one liquid-liquid extraction, which was quantified by liquid chromatography coupled to a mass spectrometer, determining the levels of paclitaxel and genistein in different biological matrices. The results of bioanalytical method validation show that using weighted (1/x2 ), the calibration curve was linear over the concentration range examined (5-2000 ng/ml for paclitaxel and 10-5000 ng/mL for genistein) with R2 > 0.98 in all the calibration curves for both analytes. The precision and inter and intra-day accuracies were evaluated in three analytical runs, analyzed on different days with triplicate samples of quality control, low, medium, high and lower limit of quantification concentrations, and had no greater variation than acceptable (15 %) showing results ranging from 85.90 to 113.80 % and 96.10 to 99.80 % recoveries for both analytes and internal standard (ketoconazole). Paclitaxel, genistein and internal standard were stable at all storage tests, both in solution and in the biological matrix (short term stability, post-processing stability) and cycles of freezing and thawing. The validated method was used to calculate the main pharmacokinetic parameters of paclitaxel and genistein in plasma after administration by intraperitoneal route: t1/2 = 2,86 e 0,89 h; tmax = 8,00 e 0,11 h; Cmax = 2,54 e 3,73 µg/mL, AUC0-14 = 19,61 e 1,96 µg *h/mL; AUC0-∞ = 21,54 e 2,01 µg*h/mL and clearance. The pharmacokinetics data indicate that this nanocarrier system features for controlled drugs release maintaining their concentrations sustained in the bloodstream, thus remaining longer at the site of administration and modular managing their biodistribution in a different way in a healthy animal and a tumor bearing animals.Item Sedação de crianças para tratamento odontológico: comparação da associação de cetamina e midazolam com midazolam isoladamente(Universidade Federal de Goiás, 2011-10-17) Moreira, Thiago Anderson Cabral; Alves Neto, Onofre; Costa, Paulo Ségio Sucasas da; Costa, Paulo Sérgio Sucasas da; Costa, Luciane Rezende Sucasas da; Jesus-França, Cristiana Marinho; Vieira, Liliani Aires CândidoChildren less than 3 years old are not expected to cooperate during dental treatment and the rapid development of dental caries led to the use of advanced methods of behavior control, such as sedation. However, there is lack of clinical trials on pediatric dental sedation. This study was performed to test (using a randomized controlled trial design) the hypothesis that young children’s behavior during dental treatment improves with oral ketamine and midazolam sedation, comparing to than isolated midazolam. Healthy children under 36 months old who had been referred to a pediatric dental sedation clinic, were randomly assigned to receive either protective stabilization (PS), oral midazolam (MS) (1.0 mg/kg) or the association of midazolam and ketamine (MK) (0.5mg/kg and 3 mg/kg). Protective stabilization was used in all groups. Child’s behavior was assessed by the Ohio State University Behavior Rating Scale (OSUBRS) at determined periods in a dental exam and treatment session. Forty two healthy children presenting early childhood caries (17 girls and 25 boys) were included. Mann- Whittney U-test demonstrated that in the first session of treatment the sum of OSUBRS score were statistically significant lower in Group MK than MS and PS groups. Friedman´s test reveled that only in Group MK OSUBRS scores did not vary significantly throughout the treatment session. Side effects were not observed. The association of oral midazolam with ketamine in dental treatment was effective to control the behavior of 1 to 3 years old children submitted to a dental treatment, but oral midazolam alone was not effective.Item Lipodistrofia: prevalência e fatores associados em pacientes adultos com HIV/AIDS(Universidade Federal de Goiás, 2014-02-21) Cardoso, Rodrigo de Castro; Silveira, Erika Aparecida da; Silveira, Erika Aparecida da; Seidl, Eliane Maria Fleury; Silva, Maria Sebastiana; Baptista, Tadeu João RibeiroDespite the improved survival and the reduced mortality in patients affected by HIV/AIDS, side effects resulting from prolonged use of the antiretroviral therapy are widely reported in the literature and, among them, the lipodystrophy stands as heterogeneous disorders in fat body metabolism showing redistribution in different parts of body. The aim of this study was to assess the prevalence of self-reported lipodystrophy and associated factors in patients with HIV/AIDS. It is nested in a cohort cross-sectional study, developed by a multidisciplinary team. The cohort was composed of 337 patients older than 19 years treated at the department of the Infectious and Parasitic Diseases, University Hospital, Federal University of Goiás, from October 2009 through July 2011. As threshold of this work and consistency of the data, 183 patients were analyzed. The self perception of the lipodystrophy was assessed by the survey on changes in distribution of body fat and the physical activity level was assessed using the International Physical Activity Survey, short version. Also, the body composition was assessed by tetrapolar bioimpedance. The data about socio-demography, anthropometry, lifestyle and medical conditions were collected. The multivariate Poisson regression analysis has the significance of 5%. The prevalence Lipodystrophy was 52.46% (95% CI 44.96 - 59.88 ), the prevalence among women was 70.73% (95% CI 1.15 to 1.95 , p = 0.008 ) and among physically active 65.28% (CI 95% 1.13 to 1.94 , p = 0.004 ) and among patients with body fat above the 95% prevalence was 71.43% (95% CI 1.23 -2.13 , p = 0.001 ). The remained significantly associated with lipodystrophy, after multivariate analysis, females (OR 1.42, 95% CI 1.09 to 1.85), being physically active, (OR 1.42, 95% CI 95% CI, 1.86) and percentage of body fat above the 95% (PR 1.41 – 1.08 1.05 to 1.91). It was observed a high prevalence of lipodystrophy, being necessary to control the body composition of these patients especially among women and the physically active groups.Item Tratamento nutricional de pacientes com AIDS: efeito sobre as alterações metabólicas, adesão ao serviço de nutrição e a dois protocolos de tratamento(Universidade Federal de Goiás, 2011-12-16) Falco, Marianne de Oliveira; Silveira, Erika Aparecida da; Bachion, Maria Márcia; Mortoza, Andrea Sugai; Turchi, Marília Dalva; Mota, João FelipeObjective: To assess the available scientific knowledge on the effect of nutritional treatment abnormality metabolic in adult patients living with Aids in the use of HAART and adherence of nutritional/diet therapy. Methods: A systematic review of literature was conducted through a search protocol developed by the authors: articles were searched in Pubmed, Lilacs and Cochrane, between 1996 and 2010, of the type: controlled clinica! triai, randomized or crossover; were adults, living with HIV/Aids under anti-retroviral therapy showing no opportunistic diseases. The intervention of interest was oral nutritional supplementation and/or lifestyle changes through specific nutritional therapy: dyslipidaemia, insulin resistance, lipodystrophy and systemic arterial hypertension. For qualitative claissification of the articles we used the Jadad scale. The clinica! triais, was controlled, randomized, open label, with a target population of adults with Aids in antiretroviral therapy and without opportunistic diseases. ln the study on adherence was held randomized controlled triai and open. Among the 165 patients randomly assi!Jned to two treatment groups for nutritional / dietary. The group treatment 1 (T1) and Treatment 2 (T2) received nutrition care, and the stage of nutritional diagnosis performed similarly in both groups and with service until completing treatment. With respect to conduct diet therapy groups (T1) and (T2) received nutritional counseling, group T2 also received individualized dietary plan. The groups had returns quaterly (T1 )i and monthly (T2). We considered dietary before and after the intervention and attendance at meetings as parameters of adherence to treatment. Results: ln a systematic review 385 papers were found and seven met the inclusion criteria. The interventions applied in such studies were: diet plus physical exercises, diet plus supplement and only supplements. Dyslipidaemia was the common outcome to all studies. The studies assessing supplementation with omega 3 found significant reduction on triglycerides. Specific diet plus omega 3 supplementation showed an increase on HDL cholesterol. Supplementation with chromo nycotinate showed no effect on dyslipidaemia. Lifestyle modification, including diet and physical activity, drastically reduced the waist circumference, lipodystrophy and systolic arterial pressure. ln the clinica! triai among 165 patients in the study were 83 T1 and 82 T2. At the end of 7,3 months, 20% patients dropped out of the nutrition therapy. The T1 and T2 groups showed no significant difference in relation to socio demographic parame1ters. 15,63% of group T2 reached the goal considered optimal for adhesion while 42.65% of group T1 were 100% adherence to queries. The T1 and T2 groups showeol a reduction to the risk of food consumption, increased consumption of protective foods, increased fractioning meals in T2 group. Conclusion: ln the systematic review by lowering triglycerides with omega 3 supplementation was the greatest nutritional intervention with scientific evidence. Prescription diet seems to be the most appropriate intervention to increase HDL. Still can not make inferences about the nutritional treatment of total cholesterol, LDL and insulin resistance. ln the study of adherence, there were no differences between groups T1 and T2, in relation to adhernnce and in relation to the goals of food consumption.Item Teste de dissolução biorrelevante aplicado à predição da bioequivalência de comprimidos de liberação imediata empregando Aparato 4 (USP) para facilitar a CIVIV(Universidade Federal de Goiás, 2013-09-30) Caricchio, Gabriella Gulde de Oliveira; Rezende, Kênnia Rocha; Rezende, Kênnia Rocha; Gil, Eric de Souza; Menegatti, RicardoThe USP- 4 dissolution apparatus have been often reported as an alternative method for in vivo in vitro correlations (IVIVC) in order to provide biowaivers. Accordingly, maintenance of sink and flow through cell conditions as well as convenience of exchanging dissolution medium are some of the advantages of such apparatus. Therefore, the achievement of biomimetic gastrointestinal tract (GIT) conditions is favored over the classic apparatus (paddle and basket). In this work, the USP- 4 apparatus was employed in order to get biorelevant dissolution methods with strong IVIVC. Dissolution profiles were achieved for the test and reference formulations containing four compounds of class II of Biopharmaceutical Classification System (BCS) – diclofenac potassium, ibuprofen, nifedipine and nimesulide, and three BCS III compounds - captopril, losartan potassium and ranitidine. Drug plasma concentrations were provided by previous bioequivalence studies (Instituto de Ciências Farmacêuticas - ICF/GO database) from human volunteers (n ≥ 24), run with the same dissolution batches. Such values were submitted to deconvolution process as defined by Wagner-Nelson method. Level C IVIVC were set by linear regression analysis of fraction dissolved (Fdiss) versus fraction absorbed (Fa). Correlation coefficient was adjusted using mutual time points of Fdiss and Fa generated in common. Obtained data showed strong correlation 30, 90, 120, 180, 240, and 360 min, for BCS II (0,81 ≤ R ≤ 0,99) compounds opposing to BCS III which IVIVC could not be found.Item Desempenho clínico de longo prazo de overdenture mandibular retida por implante unitário(Universidade Federal de Goiás, 2024-11-25) Flores, Xotchil Lourdes Tellez; Leles, Cláudio Rodrigues; http://lattes.cnpq.br/6740286066154410; Leles, Cláudio Rodrigues; Nogueira, Túlio Eduardo; Hartmann, RobertoThis study aimed to evaluate the long-term outcomes (up to 10 years) of two prospective cohorts of completely edentulous individuals treated with single implant mandibular overdenture (SIMO) opposed to a conventional maxillary complete denture. A total of 74 participants, treated between 2013 and 2016 at the School of Dentistry of the Federal University of Goiás, Brazil, were included. A single implant was placed in the mandibular midline, followed by the creation of a relief space in the complete mandibular denture, utilizing the ball O-ring retention system (Neodent, Curitiba, Paraná, Brazil), outcomes were followed for 8 -10 years. Data collected included patient satisfaction with the dentures, quality of life related to oral health through the Oral Health Impact Profile for the Edentulous (OHIP-Edent), implant survival, implant stability, peri-implant health, and incidence of prosthodontic events. Multiple regression was performed using a Generalized Linear Model due to the repeated measurements of the longitudinal data and within-implant peri-implant measures. A significance level of p<0.05 was used. Of the 74 patients, 39 were included in the 8-to-10-year follow-up. Significant improvements in OHIP-Edent scores and satisfaction were observed immediately after treatment and maintained throughout the follow-up period. Regression analyses confirmed a significant positive effect of a SIMO on these outcomes (p < 0.001). The peri-implant results indicated a favorable health status with minimal peri-implant bone changes. The most frequently observed prosthetic complication was overdenture fracture (n = 74). Additionally, the most recurrent maintenance event was matrix replacement (n = 259). SIMO demonstrated good long-term performance with minimal clinical monitoring and maintenance. The initial positive outcomes persisted for up to 10 years, suggesting that a SIMO is a low-complexity option, particularly beneficial for older patients with financial constraints